In vivo evaluation of population-specific inversion pulses in parallel transmission.

purposeThe aim of the study was to conduct in vivo evaluation of population-specific pulses in the context of the MP2RAGE sequence for brain imaging at 7T.

methodsFive clusters were identified in a cohort of 39 volunteers. One cluster centered around the average head shape and position, whereas four others were located toward the extremes of the population distribution. Additionally, the one-size-fits-all solution was considered, using a standard universal pulse (UP) approach. Head shapes were characterized using lateral head breadth (HB), anterior-posterior head length (HL), and Y-shift metrics. For each group, a 5kT-points universal inversion pulse was computed and evaluated on four new test anatomies. A Python pipeline was integrated into the image reconstruction routine, using localizer scans to classify head shapes and positions. The pipeline selected one of five precomputed population-specific pulses or defaulted to the generic UP without extending scan time.

resultsThe pipeline accurately classified head shapes and selected suitable pulses, enhancing the contrast of MP2RAGE images. Population-specific pulses helped mitigate some of the performance loss associated with using a one-size-fits-all UP, bringing performance closer to that of fully tailored solutions. This approach was particularly beneficial for individuals with smaller head sizes. However, the performance was worse in larger, more challenging head shapes.

conclusionThe novel head clustering and pulse selection pipeline facilitates the implementation of population-specific pulses in clinical practice by allowing pulse selection tailored to each head shape and position without increasing scan time.