ArticleLaboratory animal research2025
Use of H1N1 strain A/PR/8/34 influenza to build a mouse model of viral respiratory sepsis.
Article in Laboratory animal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Optimised murine model of influenza-induced respiratory sepsis for studying acute kidney injury.Laboratory animal research · 2026Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundCommunity-acquired respiratory infections are a prevalent cause of sepsis. Current animal models simulate peritoneal rather than respiratory sepsis. This study sought to appraise an influenza model for its ability to develop sepsis.
methodsTwenty-four six-week-old male BALB/c mice were intranasally inoculated with H1N1 strain A/PR/8/34 virus at 3.7 × 10
resultsOut of 24 infected mice, seven (29%) did not survive beyond 9 days. MSS predicted mortality with an AUC of 0.989 (95%CI: 0.978-1.000; P < 0.001). Liver and renal dysfunction were detected in one non-survived and six survived mice. Histological examination revealed inflammation in lung and liver but not kidney tissues.
conclusionsThis study demonstrates the potential of influenza to cause organ dysfunction, providing a basis for building a murine model specific for viral respiratory sepsis, and more closely simulating human viral sepsis.
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