Evidence map›Paper›PMID 40468421›Full record

ArticleChinese neurosurgical journal2025

Clinical characteristics and prognosis of acute stroke in pregnancy and puerperium (ASPP) patients and their offspring: a retrospective, observational, nationwide, multicenter study protocol.

Zhongji Zhang, Zihan Yin, Tong Liu, Xiaolin Zhang, Qihang Zhang, Junlin Lu, Long Mu, Yang Dong, Juning Liu, Yi Xiao and 35 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chinese neurosurgical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06527807 (Clinical Characteristics and Prognosis of Acute Stroke in Pregnancy and Puerperium), which is not on this map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06527807 recruitingnot on this map

Clinical Characteristics and Prognosis of Acute Stroke in Pregnancy and Puerperium: A Retrospective, Observational, Nationwide, Multicenter Study

TypeobservationalSponsorBeijing Tiantan HospitalRan2024 to 2025Enrolled1,200ConditionsPregnancy-associated or Puerperium-associated Acute Stroke
3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

Zhongji Zhang *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Zihan Yin *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Tong Liu *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Xiaolin ZhangDepartment of Child and Adolescent Health Care, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Qihang ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Junlin LuDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Long MuDepartment of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Yang DongDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Juning LiuDepartment of Women's Healthcare, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, China.
Yi XiaoDepartment of Women's Healthcare, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, China.
Yanming ChenDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Chenyang SongDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Zengguang WangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Yuheng LiuDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Wei DingDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Li ZhangDepartment of Neurosurgery, Baotou Central Hospital, Baotou, Inner Mongolia, China.
Huaizhang ShiDepartment of Neurosurgery, First Affiliated Hospital Harbin Medical University, Harbin, Heilongjiang, China.
Jingtao QiDepartment of Neurosurgery, First Affiliated Hospital Harbin Medical University, Harbin, Heilongjiang, China.
Bin TangDepartment of Neurosurgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Fei WangDepartment of Neurosurgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Pin GuoDepartment of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yongjun TangDepartment of Pediatric Respiratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Mingsheng YuDepartment of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, 300350, China.
Wenjian ZhengDepartment of Neurosurgery, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, 518035, China.
Qinglong HeDepartment of Neurosurgery, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Jian YuDepartment of Neurosurgery, The First Affiliated Hospital, University of Science and Technology of China, Hefei, Anhui, China.
Aihua ZhuDepartment of Neurosurgery, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.
Dazhao FangDepartment of Neurosurgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu, China.
Gang LiDepartment of Neurosurgery, Cangzhou Central Hospital, Hebei Medical University, Cangzhou, Hebei, China.
Yu BaiDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Yushuang ZhangDepartment of Pediatric, Guangyuan Central Hospital, Guangyuan, Sichuan, China.
Jiaxi LiDepartment of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yuli WangDepartment of Neurosurgery, Xinxiang Central Hospital, The Fourth Clinical College of Xinxiang Medical University, Xinxiang, Henan, 453000, China.
Faliang GaoDepartment of Neurosurgery, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Yonggang MaDepartment of Neurointerventional Surgery, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, China.
Yifan LiuShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030032, China.
Li MaDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA.
Bao YangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Yahui ZhaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Xun YeDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Qian ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Yan ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Xingju LiuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Jizong ZhaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. zhaojizong@bjtth.org.
ASPP Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies on the risk factors and prognosis of acute stroke in pregnancy and puerperium (ASPP) mainly used European and American national healthcare databases, lacking detailed patient-level data and precise event timing.

aim(1) To identify the risk factors and prognostic factors for ASPP, (2) to assess the risk of recurrent stroke, particularly during subsequent pregnancies, and (3) to evaluate offspring prognosis.

designThis study is a retrospective, observational, nationwide, multicenter research project planned to include 400 ASPP patients from 36 centers across 22 provinces in China, from 2015 to 2024. ASPP is defined as acute ischemic or hemorrhagic stroke during pregnancy or within 6 weeks postpartum, confirmed by neuroimaging. Two matched groups will be included for comparison: 400 pregnant/puerperal participants without a stroke history and 400 nonpregnant/puerperal participants with a recent stroke, matched by age and/or stroke etiology.

methodsAll participants will be followed up through telephone interviews. The initial follow-up is scheduled to take place between December 2024 and February 2025. The follow-up phase will consist of three rounds, each lasting 3 months and conducted every 3 years. Primary outcomes include unfavorable functional outcomes (mRS > 2 or EQ-5D index score < 0.7) at follow-up for Aim 1, recurrent strokes (neuroimaging-confirmed) for Aim 2, and neonatal asphyxia (Apgar scoring) and future development (ASQ-3) of offspring for Aim 3. DISCUSSION: The ASPP study is the first nationwide multicenter study to systematically evaluate the risk factors, prognosis, and risk of recurrent stroke in ASPP patients, particularly during subsequent pregnancies. This research may offer new insights into the long-term impacts of pregnancy-related stroke.

trial registrationClinicalTrials.gov (NCT06527807).

Indexed as

Acute strokeClinical characteristicsOffspringPregnancyPrognosisPuerperium

Identifiers

PMID40468421
PMCPMC12135475

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