ArticleTrials2025
Effect of 15- or 25-min intermittent Pringle maneuver on early recurrence of hepatocellular carcinoma after hepatectomy: a protocol for a randomized controlled trial.
Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundAmong various blood flow control techniques, the intermittent Pringle's maneuver (IPM) remains the most convenient and widely used method for reducing bleeding during hepatic resection (HR). However, the impact of IPM on human hepatocellular carcinoma (HCC) recurrence is still unclear. To date, no randomized controlled trial (RCT) has directly evaluated the impact of IPM on the tumor recurrence in HCC patients undergoing HR. Since 2019, our team has been investigating the effects of 25-min IPM on liver function and post-hepatectomy safety in HCC patients. To date, we have published two RCTs that confirm the safety and feasibility of 25-min IPM for HCC patients with Child-Pugh grade A liver function. However, these studies focused exclusively on short-term outcomes and did not assess tumor recurrence. Therefore, we are designing this RCT to compare the effects of 15-min IPM with 25-min IPM on early tumor recurrence in HCC patients undergoing HR.
methodsThis will be a single-center, parallel, double-blind, randomized controlled trial. A total of 334 consecutive patients who meet the inclusion and exclusion criteria will be enrolled and randomized into either the 15-min IPM group or the 25-min IPM group in a 1:1 ratio using a randomization protocol. Patients will be followed for 2 years after surgery. DISCUSSION: We designed this protocol to compare the effects of two different IPM methods on tumor recurrence in HCC patients undergoing HR, which will provide significant guidance for surgeons. Firstly, this study design is practical and feasible in clinical practice. Secondly, this RCT will encompass various types of HR procedures (including laparoscopic or open HR, as well as minor or major hepatectomy), ensuring a representative clinical application. Thirdly, to our knowledge, this is the first RCT to compare the effects of 15- and 25-min IPM on early recurrence of HCC.
trial registrationThis trial was registered on April 29, 2024, in the Chinese Clinical Trial Registry ( http://www.chictr.org.cn ), under the registration number ChiCTR2400083647. The protocol version is V1.0 (20,240,429).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.