Evidence map›Paper›PMID 40468345›Full record

ArticleJournal of biological engineering2025

Material and biological characterization of 3D knitted bioresorbable poly (D,L-lactide) (PLA) and polycaprolactone (PCL) scaffolds for soft tissue regeneration: from fabrication to in vivo performance.

Mélanie Dhayer, Vivien Barral, Damien Cleret, Amélia Jordao, Anne-Sophie Drucbert, Nicolas Germain, Sophie Dropsit, Patrice Maboudou, Salim Dekiouk, Stéphanie Brun and 5 more

Abstract read
In one paragraph

Article in Journal of biological engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mélanie DhayerInstitut de Recherche Contre Le Cancer de Lille, Univ. Lille, CNRS, CHU Lille, UMR9020 - UMR-S 1277 -Canther Cancer Heterogeneity, Plasticity and Therapy Resistance, 59000, Lille, Inserm, France.
Vivien BarralENSAIT, GEMTEX-Laboratoire de Génie et Matériaux Textiles, F- 59000 , Lille, France.
Damien CleretLattice Medical, 80 Rue du Dr Yersin, 59120, Loos, France.
Amélia JordaoInstitut de Recherche Contre Le Cancer de Lille, Univ. Lille, CNRS, CHU Lille, UMR9020 - UMR-S 1277 -Canther Cancer Heterogeneity, Plasticity and Therapy Resistance, 59000, Lille, Inserm, France.
Anne-Sophie DrucbertDrug Delivery Systems and Biomaterials, Inserm, U1008 Controlled, 59000, Lille, France.
Nicolas GermainInstitut de Recherche Contre Le Cancer de Lille, Univ. Lille, CNRS, CHU Lille, UMR9020 - UMR-S 1277 -Canther Cancer Heterogeneity, Plasticity and Therapy Resistance, 59000, Lille, Inserm, France.
Sophie Dropsit, Materia Nova-R&D Center, 7000, Mons, Belgium.
Patrice MaboudouService de Biochimie, CHU Lille, Centre de Biologie-Pathologie, 59000, Lille, France.
Salim DekioukInstitut de Recherche Contre Le Cancer de Lille, Univ. Lille, CNRS, CHU Lille, UMR9020 - UMR-S 1277 -Canther Cancer Heterogeneity, Plasticity and Therapy Resistance, 59000, Lille, Inserm, France.
Stéphanie BrunInstitut de Recherche Contre Le Cancer de Lille, Univ. Lille, CNRS, CHU Lille, UMR9020 - UMR-S 1277 -Canther Cancer Heterogeneity, Plasticity and Therapy Resistance, 59000, Lille, Inserm, France.
Christine CampagneENSAIT, GEMTEX-Laboratoire de Génie et Matériaux Textiles, F- 59000 , Lille, France.
Éric DevauxENSAIT, GEMTEX-Laboratoire de Génie et Matériaux Textiles, F- 59000 , Lille, France.
Pierre GuerreschiDrug Delivery Systems and Biomaterials, Inserm, U1008 Controlled, 59000, Lille, France.
Aurélie CaylaENSAIT, GEMTEX-Laboratoire de Génie et Matériaux Textiles, F- 59000 , Lille, France.
Philippe MarchettiInstitut de Recherche Contre Le Cancer de Lille, Univ. Lille, CNRS, CHU Lille, UMR9020 - UMR-S 1277 -Canther Cancer Heterogeneity, Plasticity and Therapy Resistance, 59000, Lille, Inserm, France. philippe.marchetti@inserm.fr.

Funding

Interreg France-Wallonie-Vlaanderen Mat(t)isse
6 · The paper itself

Abstract

backgroundSoft-tissue reconstruction is crucial in fields such as plastic surgery and oncology to address the repair of damaged tissues. Knitted scaffolds from bioresorbable copolymers, specifically poly(D,L-lactide) (PLA) and polycaprolactone (PCL), offer mechanical and biological properties that are essential for tissue engineering. This study assessed three-dimensional knitted scaffolds fabricated from melt-spun PLA and PCL multifilaments for soft tissue engineering applications. It examined the impact of the PLA/PCL ratio on the knitted scaffold structure, mechanical properties, and biological responses to determine the optimal composition for adipose tissue reconstruction.

resultsKnitted scaffolds fabricated with the PLA/PCL blends (PLA

conclusionPLA/PCL knitted scaffolds offer a promising solution for enhancing graft volume maintenance and improving long-term outcomes, with tunable mechanical properties and biodegradability. The PLA

Indexed as

Adipogenic differentiationAdipose tissueBioresorbable polymersPLA/PCL knitted scaffoldSoft tissue engineeringVascularization

Identifiers

PMID40468345
PMCPMC12139323

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.