Evidence map›Paper›PMID 40468341›Full record

ReviewJournal of experimental & clinical cancer research : CR2025

Biopiezoelectric-based nanomaterials; a promising strategy in cancer therapy.

Tingting Zuo, Saikat Dewanjee, Chao Zhang, Pratik Chakraborty, Wanxia Lu, Niraj Kumar Jha, Hiranmoy Bhattacharya, Moumita Gangopadhyay, Joshua Fleishman, Saurabh Kumar Jha and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of experimental & clinical cancer research : CR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tingting Zuo *College of Biological Sciences and Technology, Yili Normal University, Yining, 835000, China.
Saikat Dewanjee *Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700 032, West Bengal, India. saikat.dewanjee@jadavpuruniversity.in.
Chao Zhang *Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Pratik ChakrabortyAdvanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700 032, West Bengal, India.
Wanxia LuDepartment of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Niraj Kumar JhaDepartment of Biotechnology & Bioengineering, School of Biosciences & Technology, Galgotias University, Greater Noida, 203201, Uttar Pradesh, India.
Hiranmoy BhattacharyaAdvanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700 032, West Bengal, India.
Moumita GangopadhyayDepartment of Biotechnology, School of Life Science and Biotechnology, Adamas University, Barasat, 700126, Kolkata, India.
Joshua FleishmanDepartment of Pharmaceutical Science, College of Pharmacy and Health Sciences, St. John's University, Queens, NY, 11439, USA.
Saurabh Kumar JhaDepartment of Zoology, Kalindi College, University of Delhi, Delhi, 110008, India. jhasaurabh017@gmail.com.
Zhe-Sheng ChenDepartment of Pharmaceutical Science, College of Pharmacy and Health Sciences, St. John's University, Queens, NY, 11439, USA. chenz@stjohns.edu.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515011042National Natural Science Foundation of China 82373393; 22304072Open competition mechanism to select the best candidates for key research projects of Ningxia Medical University XJKF230112Xinjiang Uygur Autonomous Region Colleges and Universities Basic Research Operating Expenses Scientific Research Project XJEDU2022P106Xinjiang Uygur Autonomous Region "Tianchi Yingcai" Project 2023TCYCQNBS02
6 · The paper itself

Abstract

Cancer is one of the deadliest diseases, continually prompting physicians and researchers to investigate safe and effective modalities for its treatment. Piezoelectric nanomaterial is a new class of material with enormous potential for the nanoscale and bidirectional conversion of mechanical strain into electric fields for cancer treatment. In response to ultrasound mechanical strain, a piezopotential and electric field is generated in the tumor microenvironment, which reduces the growth of cancer cells by catalyzing redox reactions and the synthesis of reactive oxygen species. In this review, we discuss the basic concepts and mechanisms of biopiezoelectric nanomaterials as anti-cancer agents. We provide a comprehensive summary of current state-of-the-art piezoelectric nanoparticles as anti-cancer therapies. Lastly, we identify current challenges that must be addressed for the proper clinical development of biopiezoelectric nanomaterial-based anti-cancer agents and provide future perspectives for the development of this technology.

Indexed as

Antineoplastic AgentsNanostructuresNeoplasmsAnimalsHumansTumor MicroenvironmentAntineoplastic AgentsCancer therapyElectrical stimulationNanomedicinePiezocatalysisPiezoelectric materials

Identifiers

PMID40468341
PMCPMC12135266

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.