ArticleCell communication and signaling : CCS2025
Trem2 regulates microglial migratory responses via type I interferon signaling during photoreceptor degeneration.
Article in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Chrysin attenuates diabetes-induced retinal injury by inhibiting microglial GBP3/NLRP3/GSDMD-mediated pyroptosis.Animal models and experimental medicine · 2026Article
- TREM2 restrains myeloid inflammasome activation to protect against photoreceptor degeneration.Journal of neuroinflammation · 2026Article
- Long-term polystyrene nanoplastics exposure aggravates retinal inflammation and photoreceptor degeneration through microglial SPP1 signaling and neutrophil extracellular traps formation.Journal of translational medicine · 2026Article
- Photoreceptor outer segments promote the accumulation of lipid droplets in microglia by reprogramming lipid metabolism.Frontiers in immunology · 2026Article
- TREM2 in age-related macular degeneration: a microglia-centered perspective in the retinal myeloid landscape.Frontiers in ophthalmology · 2026Review
- Transcriptional downregulation of rhodopsin is associated with desensitization of rods to light-induced damage in a murine model of retinitis pigmentosa.Human molecular genetics · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundVarious functions of activated microglia play crucial roles in the progression of retinitis pigmentosa (RP). This study aims to investigate the mechanisms underlying microglial migratory responses and phagocytic activity and their effects on photoreceptor degeneration.
methodsTrem2-deficient rd10 mice (Trem2
resultsProgressive photoreceptor cell death and sustained microglial migratory responses were observed throughout the degeneration process in rd10 mice and MNU model. Trem2-deficient microglia displayed impaired migratory responses and subsequent phagocytosis, affecting photoreceptor cell survival at different stages of rd10 mice. Conversely, microglia-specific Trem2 overexpression mice showed enhanced microglial migration following MNU treatment. Furthermore, we found IFN-I signaling pathway was associated with microglial migration, which was regulated by TREM2 expression. Exogenous IFN-I blockade weakened microglial migration and reversed the effects of photoreceptor cell death caused by Trem2 overexpression.
conclusionsOur findings demonstrated the divergent roles of Trem2-mediated microglial migratory responses and phagocytic activity at different stages of RP-featured retinal degeneration models. We identified the link between Trem2 and IFN-I signaling in microglia and provided a potential microglia-associated target for RP therapy.
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