ArticleBasic and clinical andrology2025
Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score as a biomarker for phase differentiation in Peyronie's Disease: a retrospective cohort study.
Article in Basic and clinical andrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in primary versus secondary premature ejaculation: a comparative study.Basic and clinical andrology · 2026Article
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3 authors.
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Abstract
backgroundPeyronie's disease progresses through acute (inflammatory) and chronic (fibrotic) phases. Objective biomarkers for phase differentiation are lacking. Neutrophil-to-eosinophil ratio has been evaluated as an inflammatory marker in PD and reported as an important marker in the inflammatory phase. We evaluated the Hemoglobin, Albumin, Lymphocyte, and Platelet score as a non-invasive indicator of Peyronie's Disease phases.
resultsA retrospective cohort of 216 Peyronie's disease patients were analyzed. Blood parameters were collected at diagnosis (acute phase) and follow-up (chronic phase) in 112 patiens. Hemoglobin, Albumin, Lymphocyte, and Platelet scores were compared using receiver operating characteristic curves and paired t-tests. Hemoglobin, Albumin, Lymphocyte, and Platelet scores increased significantly from 36.8 ± 8.2 (acute) to 47.5 ± 10.4 (chronic) in 112 paired patients (p <0.001). Receiver operating characteristic analysis identified a cutoff of>41.2 for chronic phase detection (area under the curve = 0.83, sensitivity 76%, specificity 71%, positive predictive value 73.9%).
conclusionThe Hemoglobin, Albumin, Lymphocyte, and Platelet score is a cost-effective tool for differentiating Peyronie's Disease phases, aiding clinical decision-making.
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