Evidence map›Paper›PMID 40468210›Full record

ArticleBMC geriatrics2025

Effects of home-based, low-intensity exergaming on cognitive function of individuals with mild cognitive impairment: a study protocol for a randomized controlled trial.

Sirintip Kumfu, Somporn Sungkarat, Sirinun Boripantakul, Piangkwan Sa-Nguanmoo, Siriporn C Chattipakorn

Erratum issued Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06201533 (Effects of Low-intensity Exercise on Cognitive Function, Blood Biomarkers, and Metabolomic Alterations of Older Adults at Risk of Developing Dementia), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06201533 narecruitingnot on this map

Effects of Low-intensity Exercise on Cognitive Function, Blood Biomarkers, and Metabolomic Alterations of Older Adults at Risk of Developing Dementia

TypeinterventionalSponsorChiang Mai UniversityRan2024 to 2026Enrolled64ConditionsMild Cognitive ImpairmentArmscombined physical-cognitive exercise
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Sirintip KumfuDepartment of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Somporn SungkaratDepartment of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand. somporn.sungkarat@cmu.ac.th.
Sirinun BoripantakulDepartment of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Piangkwan Sa-NguanmooDepartment of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Siriporn C ChattipakornNeurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Funding

National Research Council of Thailand (NRCT) N42A660640
6 · The paper itself

Abstract

backgroundAlthough older adults with Mild Cognitive Impairment (MCI) face an increased risk of dementia, accumulating evidence has revealed that their cognitive functions could revert to normal levels with effective interventions. Exercise, particularly a combination of physical and cognitive training delivered in the form of an exergame, has shown promising effects in improving cognitive function of older adults with MCI. Nonetheless, previous research often prescribed center-based, moderate to vigorous intensity exercise, posing potential risks to older adults with physical or medical conditions as well as limiting accessibility for those with schedule or transportation constraints. Therefore, this study aims to evaluate the effects of home-based, low-intensity, combined physical-cognitive exercise in the form of an exergame, on cognitive function in individuals with MCI and to further investigate potential biomarkers linking the effectiveness of the exercise program to cognitive alterations.

methodsSixty-four older adults with MCI will be enrolled and randomly allocated to either the exercise group or the control group. The exercise group will engage in a low-intensity, combined physical-cognitive exercise through an exergame, with a 50-minute session, 3 times per week for 12 consecutive weeks. The control group will not receive any intervention. Primary outcome measures will be cognitive performance (global cognition, executive function, memory, and attention), and secondary outcome measures will be plasma biomarkers and physical performance. All assessments will be administered at baseline and after a 12-week intervention. DISCUSSION: The findings of this study might provide valuable insights into an effective and practical intervention program aimed at improving cognitive function of older adults with MCI. The low-intensity, home-based exergaming could have considerable clinical implications, as it has the potential to enhance accessibility for individuals who are unable to engage in high-intensity exercise or attend center-based exercise programs.

trial registrationClinicalTrials.gov identifier: NCT06201533, Registered January 11, 2024.

Indexed as

CognitionCognitive DysfunctionExerciseExercise TherapyVideo GamesAgedAged, 80 and overFemaleHumansMaleRandomized Controlled Trials as TopicCognitive functionExergameHome-based exerciseLow-intensityMild cognitive impairment

Identifiers

PMID40468210
PMCPMC12139151

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.