ArticleBMC medical imaging2025
Computed tomography-based radiomics model for predicting station 4 lymph node metastasis in non-small cell lung cancer.
Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Development and validation of an interpretable machine learning model for prediction of occult lymph node metastasis in clinical stage T1 lung adenocarcinoma.Translational lung cancer research · 2025Article
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9 authors.
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Abstract
backgroundThis study aimed to develop and validate machine learning models for preoperative identification of metastasis to station 4 mediastinal lymph nodes (MLNM) in non-small cell lung cancer (NSCLC) patients at pathological N0-N2 (pN0-pN2) stage, thereby enhancing the precision of clinical decision-making.
methodsWe included a total of 356 NSCLC patients at pN0-pN2 stage, divided into training (n = 207), internal test (n = 90), and independent test (n = 59) sets. Station 4 mediastinal lymph nodes (LNs) regions of interest (ROIs) were semi-automatically segmented on venous-phase computed tomography (CT) images for radiomics feature extraction. Using least absolute shrinkage and selection operator (LASSO) regression to select features with non-zero coefficients. Four machine learning algorithms-decision tree (DT), logistic regression (LR), random forest (RF), and support vector machine (SVM)-were employed to construct radiomics models. Clinical predictors were identified through univariate and multivariate logistic regression, which were subsequently integrated with radiomics features to develop combined models. Models performance were evaluated using receiver operating characteristic (ROC) analysis, calibration curves, decision curve analysis (DCA), and DeLong's test.
resultsOut of 1721 radiomics features, eight radiomics features were selected using LASSO regression. The RF-based combined model exhibited the strongest discriminative power, with an area under the curve (AUC) of 0.934 for the training set and 0.889 for the internal test set. The calibration curve and DCA further indicated the superior performance of the combined model based on RF. The independent test set further verified the model's robustness.
conclusionsThe combined model based on RF, integrating radiomics and clinical features, effectively and non-invasively identifies metastasis to the station 4 mediastinal LNs in NSCLC patients at pN0-pN2 stage. This model serves as an effective auxiliary tool for clinical decision-making and has the potential to optimize treatment strategies and improve prognostic assessment for pN0-pN2 patients. CLINICAL TRIAL NUMBER: Not applicable.
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