ArticleBMC geriatrics2025
Inflammatory markers and clinical factors as key independent risk factors for frailty: a retrospective study.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Characterization of Models for Identifying Physical and Cognitive Frailty in Older Adults With Diabetes: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Interpretable machine learning framework for frailty risk prediction using NHANES 2007-2018: A cross-sectional study.Medicine · 2026Article
- Albuminuria Levels and Geriatric Outcomes in Predialysis: Chronic Kidney Disease: Falls, Fear of Falling, and Frailty in a Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Inflammation and sarcopenia exhibit distinct associations with psychopathology and executive function in schizophrenia.Journal of the Chinese Medical Association : JCMA · 2026Article
- Association between the albumin-to-globulin ratio and deep vein thrombosis in older adults receiving home healthcare: a prospective cohort study.Irish journal of medical science · 2026Article
- L-shaped association of plasma creatinine with frailty in oldest‑old: Evidence from a cross-sectional study of CLHLS.Scientific reports · 2026Article
- Frailty assessment tools in the emergency department and their predictive value for clinical outcomes: review of the literature.GeroScience · 2026Review
- Association between different dimensions of C-reactive protein-triglyceride-glucose index and the incidence of frailty in middle-aged and elderly adults in China: a nationwide prospective cohort study.Lipids in health and disease · 2026Article
- Clinical Relevance of Preoperative Lymphocyte-to-Monocyte Ratio in Predicting Postoperative Delirium Across Frailty Status in Older Surgical Patients.Clinical interventions in aging · 2026Article
- Article
- New insights into the association between cardiometabolic index with metabolic profile, nutritional status, and inflammaging in older adults.Frontiers in aging · 2025Article
- Sex Differences in the Association Between Inflammatory Biomarkers (Hs-CRP, IL-6, IL-10, TNF-α) and Frailty in Hospitalized Adults Aged ≥65 in Taizhou, China: A Cross-Sectional Study.Clinical interventions in aging · 2025Article
- Association of the dietary inflammation index with frailty in middle-aged and older adults: a systematic review and meta-analysis.Frontiers in nutrition · 2025Review
Corrections and comments
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4 authors.
Funding
Abstract
BACKGROUND AND
objectiveFrailty in older adults leads to falls, disability, hospitalization, and death. Identifying frail individuals is a crucial means to delay the onset of adverse results. Chronic inflammation plays a key role in the onset and progression of frailty. Our study aims to explore the relationship between inflammatory markers and frailty in older adults, thereby contributing to more accurate assessments of frailty.
methodsWe included 4,097 cases aged ≥ 60 years admitted to the Geriatrics Department of Beijing Friendship Hospital between July 17, 2018 and February 27, 2024, 800 cases were ultimately included. Patients were divided into non-frail, pre-frail, and frail groups based on the Fried frailty phenotype. Logistic regression analyses were performed using "Python's statsmodels library" to identify risk factors. "The Sklearn library" was used to assess the predictive power of these factors.
resultsTwo hundred five individuals were identified as frail. Independent risk factors for frailty included age, coronary artery disease (CAD), old cerebral infarction (OCI), neutrophil, neutrophil to lymphocyte rate (NLR), high-sensitivity C-reactive protein (hs-CRP), albumin, fibrinogen to albumin ratio (FAR) and erythrocyte sedimentation rate (ESR). Receiver operating characteristic curve analysis of age, CAD, OCI, neutrophils, NLR, hs-CRP, albumin, FAR, and ESR showed AUCs of 0.851 and 0.841 for logistic regression and random forest models.
conclusionInflammatory markers such as NLR, hs-CRP, FAR, and ESR, along with age, OCI, and CAD, were key independent risk factors for frailty. Incorporating these factors into predictive models could enhance frailty prediction.
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