Evidence map›Paper›PMID 40468081›Full record

ArticleNature2025

Molecular gradients shape synaptic specificity of a visuomotor transformation.

Mark Dombrovski, Yixin Zang, Giovanni Frighetto, Andrea Vaccari, HyoJong Jang, Parmis S Mirshahidi, Fangming Xie, Piero Sanfilippo, Bryce W Hina, Aadil Rehan and 9 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Cell-type-specific circadian and light-responsive transcriptional dynamics in adultProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Binocular Circuitry as a Model for Understanding Experience-Dependent Circuit Development across the Mammalian Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Graph embeddings for identifying symmetries in Connectomes.bioRxiv : the preprint server for biology · 2025
    Article
  10. Regulatory logic of neuronal identity specification inbioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Mark DombrovskiDepartment of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Yixin Zang *Department of Neuroscience, Howard Hughes Medical Institute, The Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.ORCID 0000-0003-0900-8052
Giovanni Frighetto *Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-7461-3916
Andrea Vaccari *Department of Computer Science, Middlebury College, Middlebury, VT, USA.ORCID 0000-0002-3356-326X
HyoJong Jang *School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA.
Parmis S Mirshahidi *Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Fangming XieDepartment of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Piero SanfilippoDepartment of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Bryce W HinaSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA.
Aadil RehanDepartment of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0009-0001-8016-4544
Roni H HusseinDepartment of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Pegah S MirshahidiDepartment of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Catherine LeeDepartment of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0009-0002-2192-6497
Aileen MorrisDepartment of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Mark A FryeDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-3277-3094
Catherine R von ReynSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA.
Yerbol Z KurmangaliyevDepartment of Biology, Brandeis University, Waltham, MA, USA.
Gwyneth M CardDepartment of Neuroscience, Howard Hughes Medical Institute, The Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. gc3017@columbia.edu.ORCID 0000-0002-7679-3639
S Lawrence ZipurskyDepartment of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. lzipursky@mednet.ucla.edu.ORCID 0000-0001-5630-7181

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Cale Whitworth · 2014 to 2026
$13.5M
Neural circuits for visual feature detectionR01EY026031 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Mark Arthur Frye, Patrick A Shoemaker · 2016 to 2026
$3.9M
Neural algorithms underlying diversity in visual feature integrationR01NS118562 · NINDS · DREXEL UNIVERSITY · PI VON REYN, CATHERINE R · 2020 to 2024
$2.8M
Neuronal mechanisms of selective visual attentionK99EY036889 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Giovanni Frighetto · 2025 to 2026
$236k
Molecular determinants of synaptic specificity underlying a visuomotor transformationK99EY036123 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DOMBROVSKIY, MARK · 2024 to 2025
$220k
NEI NIH HHS K99 EY036123NEI NIH HHS K99 EY036889NEI NIH HHS R01 EY026031NIH HHS P40 OD018537NINDS NIH HHS R01 NS118562
6 · The paper itself

Abstract

How does the brain convert visual input into specific motor actions

Indexed as

Drosophila melanogasterSynapsesAnimalsDrosophila ProteinsFemaleMaleMotion PerceptionNeuronsVisual PathwaysDrosophila Proteins

Identifiers

PMID40468081
PMCPMC12350164

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.