Evidence map›Paper›PMID 40468079›Full record

ArticleNature2025

Ischaemic endothelial necroptosis induces haemolysis and COVID-19 angiopathy.

Mike C L Wu, Ethan Italiano, Rocko Jarvis-Child, Imala Alwis, Rhyll Smythe, Eduardo A Albornoz, Jonathan Noonan, Marie Portelli, Marissa Baptista, Jessica Maclean and 13 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Mike C L WuThe Heart Research Institute, Sydney, New South Wales, Australia.ORCID 0000-0002-4039-4409
Ethan ItalianoThe Heart Research Institute, Sydney, New South Wales, Australia.ORCID 0009-0006-8170-7105
Rocko Jarvis-ChildThe Heart Research Institute, Sydney, New South Wales, Australia.ORCID 0009-0002-2095-5157
Imala AlwisThe Heart Research Institute, Sydney, New South Wales, Australia.
Rhyll SmytheThe Heart Research Institute, Sydney, New South Wales, Australia.ORCID 0009-0002-3652-6197
Eduardo A AlbornozSchool of Biomedical Sciences, University of Queensland, St Lucia, Queensland, Australia.ORCID 0000-0002-9976-6350
Jonathan NoonanAtherothrombosis and Vascular Biology Program, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.ORCID 0000-0001-9173-0903
Marie PortelliThe Heart Research Institute, Sydney, New South Wales, Australia.
Marissa BaptistaThe Heart Research Institute, Sydney, New South Wales, Australia.
Jessica MacleanThe Heart Research Institute, Sydney, New South Wales, Australia.
Pashtana NooriThe Heart Research Institute, Sydney, New South Wales, Australia.
Jinglu YangThe Heart Research Institute, Sydney, New South Wales, Australia.
John D LeeSchool of Biomedical Sciences, University of Queensland, St Lucia, Queensland, Australia.
James D McFadyenAtherothrombosis and Vascular Biology Program, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Alexandra F SharlandCharles Perkins Centre, University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0003-1579-5398
Trent M WoodruffSchool of Biomedical Sciences, University of Queensland, St Lucia, Queensland, Australia.ORCID 0000-0003-1382-911X
Andre L SamsonWalter and Eliza Hall Research Institute (WEHI), Parkville, Victoria, Australia.ORCID 0000-0002-0637-2716
Amy RapkiewiczNew York University Winthrop Hospital, Department of Pathology, Long Island School of Medicine, Mineola, NY, USA.
Tessa J BarrettGrossman School of Medicine, New York University, New York, NY, USA.
Alan PhamDepartment of Anatomical Pathology, The Alfred Hospital, Melbourne, Victoria, Australia.
Simone M SchoenwaelderThe Heart Research Institute, Sydney, New South Wales, Australia.ORCID 0000-0003-0465-5840
Yuping Yuan *The Heart Research Institute, Sydney, New South Wales, Australia.
Shaun P Jackson *The Heart Research Institute, Sydney, New South Wales, Australia. shaun.jackson@thrombio.com.au.ORCID 0000-0002-4750-1991

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microangiopathy is a major complication of SARS-CoV-2 infection and contributes to the acute and chronic complications of the disease

Indexed as

COVID-19Endothelial CellsHemolysisIschemiaNecroptosisAnimalsErythrocytesFemaleHumansMaleMiceMicrovesselsProtein KinasesReperfusion InjurySARS-CoV-2MLKL protein, humanMLKL protein, mouseProtein Kinases

Identifiers

PMID40468079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.