Evidence map›Paper›PMID 40468078›Full record

ArticleNature2025

A multidimensional distributional map of future reward in dopamine neurons.

Margarida Sousa, Pawel Bujalski, Bruno F Cruz, Kenway Louie, Daniel C McNamee, Joseph J Paton

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. A hardwired neural circuit for temporal difference learning.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Mesolimbic dopamine ramps reflect environmental timescales.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Margarida SousaChampalimaud Centre for the Unknown, Lisbon, Portugal.
Pawel BujalskiChampalimaud Centre for the Unknown, Lisbon, Portugal.ORCID 0000-0001-6653-1996
Bruno F CruzChampalimaud Centre for the Unknown, Lisbon, Portugal.
Kenway LouieCenter for Neural Science, New York University, New York, NY, USA.
Daniel C McNameeChampalimaud Centre for the Unknown, Lisbon, Portugal.ORCID 0000-0001-9928-4960
Joseph J PatonChampalimaud Centre for the Unknown, Lisbon, Portugal. joe.paton@neuro.fchampalimaud.org.ORCID 0000-0002-1663-6455

Funding

U19 Supplement 2023-FroemkeU19NS107616 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Adam Christopher Mar · 2018 to 2026
$36.4M
NINDS NIH HHS U19 NS107616
6 · The paper itself

Abstract

Midbrain dopamine neurons (DANs) signal reward-prediction errors that teach recipient circuits about expected rewards

Indexed as

Dopaminergic NeuronsRewardAlgorithmsAnimalsAnticipation, PsychologicalCuesFemaleMaleMesencephalonMiceMice, Inbred C57BLModels, NeurologicalOptogeneticsProbabilityReinforcement, PsychologyTime Factors

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.