ArticleNature2025
Loss of colonic fidelity enables multilineage plasticity and metastasis.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Tissue-derived extracellular matrix hydrogels instruct epigenetic adaptation in metastatic colonization.Bioactive materials · 2027Article
- Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis.Cell stem cell · 2026Article
- Transcriptomic profiling identifies immunotherapy-responsive phenotypes in microsatellite-stable metastatic colorectal cancer.Oncogene · 2026Article
- Progressive intestinal tumor cell plasticity, Myc activation, and loss of Lgr5Science advances · 2026Article
- KMT2D loss drives adeno-to-squamous transition and sensitizes TKI-resistant lung cancer to AURKA inhibition.Cell death and differentiation · 2026Article
- Article
- Article
- Squamous-state excursions activate APOBEC3A in cancer.bioRxiv : the preprint server for biology · 2026Article
- AScience signaling · 2026Article
- Targeting the epigenome and the integrated stress response to normalize colorectal cancer subclonal plasticity and progression.Cell death & disease · 2026Article
- A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer.Cancer discovery · 2026Article
- An Integrative Roadmap for Advancing Colorectal Cancer Organoid.Biomedicines · 2026Article
- Understanding Liver and Digestive Diseases: A Paved Road to Improve Diagnosis, Management, and Treatment.Exploration of digestive diseases · 2026Article
- Oncofetal reprogramming and cellular plasticity in colorectal cancer: from mechanisms to clinical translation.Frontiers in oncology · 2026Review
- Review
- From Cells to Organoids: Approaches, Regulatory Mechanisms, Applications, and Challenges of Organoids.Cells · 2025Review
- A robust classifier for the intrinsic consensus molecular subtypes in colorectal cancer.Journal of translational medicine · 2025Article
- Deciphering the immunocellular regulatory network in inflammatory bowel disease: from susceptibility genes to cellular effectors and toward precision therapies.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors.
Patrizia CammareriInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.
Michela RaponiInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID 0009-0002-0448-1836
Yourae HongMolecular Digestive Oncology, Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium.ORCID 0000-0001-6683-433X
Caroline V BillardInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID 0000-0003-4953-353X
Nat PeckettInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID 0000-0003-0134-1344
Yujia ZhuInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.
Fausto D Velez-BravoMolecular Digestive Oncology, Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium.ORCID 0000-0002-8596-3943
Nicholas T YoungerInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.
Donnchadh S DunicanMRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.
Sebastian Ö-G PohlInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID 0000-0002-4294-9498
Aslihan Bastem AkanInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.
Nora J DoleschallInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID 0000-0002-4981-7156
John FalconerCancer Research UK Scotland Institute, Glasgow, UK.
Mark WhiteCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0002-6309-3254
Jean QuinnSchool of Cancer Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0002-8267-0993
Kathryn PennelSchool of Cancer Sciences, University of Glasgow, Glasgow, UK.
Roberta GarauInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.
Sudhir B MallaCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0001-5862-3815
Philip D DunneCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0001-9160-283X
Richard R MeehanMRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID 0000-0001-6471-6882
Owen J SansomCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0001-9540-3010
Joanne EdwardsSchool of Cancer Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0002-7192-6906
Malcolm G DunlopInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID 0000-0002-3033-5851
Farhat V N DinInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID 0000-0001-5466-8282
Sabine TejparMolecular Digestive Oncology, Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium.ORCID 0000-0003-3281-8643
Colin W SteeleCancer Research UK Scotland Institute, Glasgow, UK.
Kevin B MyantInstitute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK. kevin.myant@ed.ac.uk.ORCID 0000-0001-8017-1093
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer cell plasticity enables the acquisition of new phenotypic features and is implicated as a major driver of metastatic progression
Indexed as
Cell LineageCell PlasticityColonColorectal NeoplasmsNeoplasm MetastasisAnimalsCell Line, TumorChromatinChromatin Assembly and DisassemblyEnhancer Elements, GeneticEpigenesis, GeneticEpithelial CellsFemaleGene Expression Regulation, NeoplasticHepatocyte Nuclear Factor 4HumansATRX protein, humanChromatinHepatocyte Nuclear Factor 4HNF4A protein, humanX-linked Nuclear Protein
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.