Evidence map›Paper›PMID 40468068›Full record

ArticleNature2025

Maternal iron deficiency causes male-to-female sex reversal in mouse embryos.

Naoki Okashita, Ryo Maeda, Shunsuke Kuroki, Kyona Sasaki, Yoko Uno, Peter Koopman, Makoto Tachibana

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Naoki OkashitaLaboratory of Epigenome Dynamics, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan.
Ryo MaedaLaboratory of Epigenome Dynamics, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan.ORCID 0000-0003-3302-7392
Shunsuke KurokiLaboratory of Epigenome Dynamics, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan.
Kyona SasakiLaboratory of Epigenome Dynamics, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan.
Yoko UnoLaboratory of Epigenome Dynamics, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan.
Peter KoopmanInstitute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Makoto TachibanaLaboratory of Epigenome Dynamics, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan. tachibana.makoto.fbs@osaka-u.ac.jp.ORCID 0000-0001-7977-1120

Funding

Chubei Itoh Foundation (N.O.), the Tojuro Iijima Foundation for Food Science and Technology (N.O.), the Food Science Institute Foundation (N.O.), the Terumo Life Science Foundation (M.T.), the Uehara Memorial Foundation (M.T) and JSPS KAKENHI
6 · The paper itself

Abstract

Ferrous iron (Fe

Indexed as

Embryo, MammalianIron DeficienciesSex Determination ProcessesAnimalsFemaleGonadsHistonesIronJumonji Domain-Containing Histone DemethylasesMaleMethylationMiceOvaryPregnancySex-Determining Region Y ProteinHistonesIronJumonji Domain-Containing Histone DemethylasesKdm3a protein, mouseSex-Determining Region Y ProteinSry protein, mouse

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.