Evidence map›Paper›PMID 40468060›Full record

ArticleSleep & breathing = Schlaf & Atmung2025

Low total protein predicts adverse outcomes in patients with chronic obstructive pulmonary disease.

Yiben Huang, Jianing Wang, Zicong Dai, Binbin Hu, Siyao Chen, Xuanyang Chen, Chunyan Liu, Wanzhong Jin, Beibei Yu, Xiaodiao Zhang

Abstract read
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In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yiben HuangDepartment of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Jianing WangDepartment of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Zicong DaiDepartment of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Binbin HuDepartment of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Siyao ChenDepartment of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Xuanyang ChenDepartment of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Chunyan LiuDepartment of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Wanzhong JinDepartment of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Beibei YuDepartment of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. YBB2469@126.com.
Xiaodiao ZhangDepartment of Respiratory and Critical Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. xiaodiao_zhang@126.com.

Funding

Wenzhou Municipal Sci-Tech Bureau Program No.Y20210842
6 · The paper itself

Abstract

purposeTotal protein (TP), comprising albumin and globulin, is a common and readily available indicator. This study aimed to assess the correlation between total protein and disease severity as well as exercise tolerance in patients with stable chronic obstructive pulmonary disease (COPD).

methodsA total of 84 patients with COPD were recruited in this study. Plasma total protein levels, body mass index, air-flow obstruction, dyspnea, exercise capacity (BODE) index, the six-minute walking distance (6MWD), lung function and other relevant data were recorded. Patients were divided into three groups according to TP tertiles. Receiver operating characteristic (ROC) curves were used to evaluate the performance of TP in predicting severe COPD (BODE ≥ 5). Besides, logistic regression analyses were conducted to assess whether TP was an independent factor associated with BODE grades.

resultsCOPD subjects with TP levels below 61.2 exhibited a significantly higher proportion of severe COPD. Logistic regression analyses substantiated that TP was associated with COPD severity. Compared with albumin and globulin levels, TP levels showed the highest accuracy in predicting a high BODE index in COPD (BODE ≥ 5) (the area under the ROC curve (AUC) = 0.789). Moreover, TP was positively related to 6WMD during the first 30 days of admission.

conclusionsA lower level of TP was associated with a higher BODE index, indicating more severe COPD.

Indexed as

Blood ProteinsPulmonary Disease, Chronic ObstructiveAgedExercise ToleranceFemaleHumansMaleMiddle AgedPrognosisSeverity of Illness IndexBlood ProteinsChronic obstructive pulmonary diseaseDisease severityExercise toleranceTotal protein

Identifiers

PMID40468060

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.