Evidence map›Paper›PMID 40468037›Full record

ArticleCardiovascular and interventional radiology2025

Hepatic Histotripsy: Jet Ventilation Decreases the Effect of Respiratory Motion in A Porcine Liver Model.

J Erik Winterholler, Meridith A Kisting, Katrina L Falk, Adrienne L Kisting, Madeline S Jentink, Jim K White, Meghan G Lubner, Paul F Laeseke, Erica M Knavel Koepsel, John F Swietlik and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular and interventional radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Injectable radiopaque targets for cone-beam CT guided histotripsy.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

J Erik WinterhollerDepartments of Radiology, University of Wisconsin Hospitals and Clinics, 600 Highland Avenue, Madison, WI, 53792, USA.
Meridith A KistingCarle Illinois College of Medicine, 506 S Mathews Ave, Urbana, IL, 61801, USA.
Katrina L FalkBiomedical Engineering, University of Wisconsin Hospitals and Clinics, 600 Highland Avenue, Madison, WI, 53792, USA.
Adrienne L KistingDepartments of Radiology, University of Wisconsin Hospitals and Clinics, 600 Highland Avenue, Madison, WI, 53792, USA.
Madeline S JentinkDepartments of Radiology, University of Wisconsin Hospitals and Clinics, 600 Highland Avenue, Madison, WI, 53792, USA.
Jim K WhiteDepartments of Radiology, University of Wisconsin Hospitals and Clinics, 600 Highland Avenue, Madison, WI, 53792, USA.
Meghan G LubnerDepartments of Radiology, University of Wisconsin Hospitals and Clinics, 600 Highland Avenue, Madison, WI, 53792, USA.
Paul F LaesekeDepartments of Radiology, University of Wisconsin Hospitals and Clinics, 600 Highland Avenue, Madison, WI, 53792, USA.
Erica M Knavel KoepselDepartments of Radiology, University of Wisconsin Hospitals and Clinics, 600 Highland Avenue, Madison, WI, 53792, USA.
John F SwietlikDepartments of Radiology, University of Wisconsin Hospitals and Clinics, 600 Highland Avenue, Madison, WI, 53792, USA.
J Louis HinshawDepartments of Radiology, University of Wisconsin Hospitals and Clinics, 600 Highland Avenue, Madison, WI, 53792, USA.
Tatiana H FerreiraDepartment of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI, 53706, USA.
Lu MaoBiostatistics and Medical Informatics, University of Wisconsin Hospitals and Clinics, 600 Highland Avenue, Madison, WI, 53792, USA.
Timothy McCormickAnesthesia University of Wisconsin Hospitals and Clinics, 600 Highland Avenue, Madison, WI, 53792, USA.
Min CuiDepartment of Pathology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave, Cleveland, OH, 44106, USA.
Fred T LeeDepartments of Radiology, University of Wisconsin Hospitals and Clinics, 600 Highland Avenue, Madison, WI, 53792, USA.
Timothy J ZiemlewiczDepartments of Radiology, University of Wisconsin Hospitals and Clinics, 600 Highland Avenue, Madison, WI, 53792, USA. tziemlewicz@uwhealth.org.ORCID http://orcid.org/0000-0002-7033-1062

Funding

Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Advanced multimodal image-guided histotripsy for precise, safe and effective histotripsy of liver tumorsR01EB031007 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI Paul F Laeseke, Martin Gerd Wagner · 2022 to 2026
$2.5M
Developing Methods for Precise, Safe and Target-location Specific Histotripsy of Liver TumorsR01CA262474 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI ZIEMLEWICZ, TIMOTHY J · 2021 to 2025
$2.4M
Developing an Accurate and Robust Targeting Technique to Enable Transcostal Histotripsy Treatment of Liver TumorsF30CA284541 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Katrina Lauren Falk · 2024 to 2026
$135k
NCI NIH HHS F30 CA284541NCI NIH HHS F30CA284541NCI NIH HHS R01 CA262474NIBIB NIH HHS R01 EB031007NIGMS NIH HHS T32 GM140935NIGMS NIH HHS T32GM140935NIH HHS RO1CA262474NIH HHS RO1EB031007
6 · The paper itself

Abstract

purposeTo determine the efficacy of high-frequency jet ventilation (HFJV) to reduce the effects of respiratory motion on the resultant treatment zone during hepatic histotripsy in an in vivo porcine model. MATERIALS AND

methodsNon-tumor bearing swine (n = 6, 50.1 kg) underwent hepatic histotripsy with both HFJV and conventional ventilation (CV) in separate locations. Treatments were followed by contrast-enhanced magnetic resonance imaging (MRI) and necropsy. Treatment zone size (with emphasis on the cranial-caudal (CC) dimension), volume, and a survey for complications were conducted by MRI and at necropsy. Histopathology was performed to confirm complete cell kill in the treatment zone. Treatment precision was assessed by the width of the transition zone (TZ, zone of partial treatment) with a narrower TZ denoting increased precision.

resultsAnimals tolerated treatments with no adverse events. Treatment zones created during HFJV were less elongated than during CV (CC dimension during HFJV = 27.8 mm vs. CV = 32.3 mm, p = 0.04). Mean TZ width (treatment precision) was narrower in the HFJV group (HFJV = 4.1 mm, CV = 6.9 mm, p < 0.001), particularly at the cranial margin (HFJV = 4.0 mm, CV = 8.2, p = 0.018). Off-target treatments occurred in the chest wall (n = 2) and spleen (n = 1).

conclusionHigh-frequency jet ventilation reduces the craniocaudal elongation of histotripsy treatment zones caused by respiratory motion and improves the precision of histotripsy compared to conventional ventilation in this animal model.

Indexed as

High-Frequency Jet VentilationLiverAnimalsContrast MediaDisease Models, AnimalMagnetic Resonance ImagingModels, AnimalSwineContrast MediaAblationAnesthesiaHistotripsyUltrasound

Identifiers

PMID40468037
PMCPMC12325549

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.