ArticleCommunications biology2025
Transglutaminase 2-expressing macrophages modulate adipose tissue inflammation.
Diana M Elizondo, Tushar P Patel, Benjamin T Cole, Eliza A Jansujwicz, Jocelyn Chen, Melanie C Hollis, Apratim Mitra, Jack A Yanovski
Abstract read
In one paragraphArticle in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Diana M ElizondoSection on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA.
Tushar P PatelSection on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-7823-2579 Benjamin T ColeSection on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0009-0009-6816-0266 Eliza A JansujwiczSection on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA.
Jocelyn ChenSection on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA.
Melanie C HollisSection on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA.
Apratim MitraBioinformatics and Scientific Programming Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA.
Jack A YanovskiSection on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, USA. jy15i@nih.gov.ORCID http://orcid.org/0000-0001-8542-1637 Funding
Physiology, Psychology, and Genetics of ObesityZIAHD000641 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YANOVSKI, JACK A. · 2009 to 2025
$24.8MIntramural NIH HHS ZIA HD000641NIDDK NIH HHS K99 DK136921U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) ZIAHD00641
6 · The paper itselfAbstract
We investigated Transglutaminase 2 (TGM2) in high fat diet (HFD) obese mice, finding upregulated TGM2+ adipose tissue macrophages (ATMs) in HFD epididymal white adipose tissue (eWAT) compared to chow diet (CD) eWAT. Using Tgm2 CRISPR silencing, we examined TGM2 modulation of inflammation in vitro within bone marrow-derived macrophages (BMMs), as well as in co-cultured eWAT stromal vascular fraction (SVF) cells. Tgm2 silencing in BMMs led to increased pro-inflammation, compared to control. In contrast, in vitro exposure of eWAT SVF to recombinant TGM2 increased anti-inflammatory IL-10 secretion. However, IL-10 was not induced by recombinant TGM2 in CD activated CD4 + T cells, or in HFD-derived SVF CD4 + T cells. In vivo Tgm2 silencing in CD11b+ cells in HFD mice resulted in pro-inflammation in eWAT and serum, and increased adiposity and insulin resistance, suggesting that TGM2 + ATMs possess an anti-inflammatory role in obesity that is insufficient to reverse obesity-induced inflammation.
Indexed as
Adipose TissueAdipose Tissue, WhiteGTP-Binding ProteinsInflammationMacrophagesObesityTransglutaminasesAnimalsDiet, High-FatMaleMiceMice, Inbred C57BLProtein Glutamine gamma Glutamyltransferase 2GTP-Binding ProteinsProtein Glutamine gamma Glutamyltransferase 2Transglutaminases
Identifiers
PMID40467990
PMCPMC12137700
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