Evidence map›Paper›PMID 40467978›Full record

ArticlePediatric research2025

Vitamin C for neuroprotection in neonatal encephalopathy.

Raul Chavez-Valdez, Nazli Kuter, Srishti Jayakumar

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Raul Chavez-ValdezDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA. rchavez2@jhmi.edu.ORCID 0000-0002-0788-8028
Nazli KuterDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Srishti JayakumarDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this commentary, we provide additional context to interpret the findings reported on the manuscript by Liu et al., "Neuroprotective effects of vitamin C on hypoxic-ischemic brain injury in neonatal mice" published in this issue of Pediatric Research. IMPACT: Vitamin C is an anti-oxidant with anti-inflammatory effects, which may be neuroprotective against neonatal hypoxic-ischemic (HI) brain injury in a preterm mouse model Several experimental caveats include the timing of intervention, model use and side effects. We provide additional context to the reader in the interpretation of the data.

Indexed as

Ascorbic AcidBrain DiseasesHypoxia-Ischemia, BrainNeuroprotectionNeuroprotective AgentsAnimalsAnimals, NewbornAntioxidantsDisease Models, AnimalHumansInfant, NewbornMiceAntioxidantsAscorbic AcidNeuroprotective Agents

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.