Observational studyPediatric research2025
Preterm infants on high-frequency oscillatory ventilation: electrical impedance tomography during lung recruitment.
Observational study in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Are we ready to consider lung recruitability during mechanical ventilation of neonates?Pediatric research · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe introduce a novel physiological parameter derived from electrical impedance tomography (EIT) to evaluate oxygenation-guided lung recruitment maneuvers in preterm infants on high-frequency oscillatory ventilation (HFOV).
methodsIn this prospective observational study, EIT was performed during a single, stepwise oxygenation-guided lung recruitment maneuver in extremely preterm infants. At each step of continuous distending pressure (CDP), we calculated the median oscillations in the aerated region (MOR), defined as the median of oscillatory impedance amplitudes within the air-containing region multiplied by the number of pixels in that region. Recruitability was determined by a ≥15% increase in MOR or oxygenation (S/F-ratio) during deflation compared to inflation at any CDP. Gas exchange parameters were compared between lungs identified as recruitable for MOR or oxygenation.
resultsOf the 56 EIT measurements from 47 infants (mean weight 685 ± 140 g) analyzed, 43 lungs were recruitable by oxygenation criteria, but only 23 met recruitability criteria based on MOR. MOR-recruitable maneuvers significantly improved transcutaneous pCO
conclusionsThe novel EIT parameter, MOR, helps identify effective lung recruitment maneuvers and detect overdistention in extremely preterm infants on HFOV, offering the potential to distinguish beneficial from harmful maneuvers. IMPACT: We introduced a novel parameter, the median oscillations in aerated lung regions (MOR), derived from electrical impedance tomography (EIT), to evaluate oxygenation-guided lung recruitment in preterm infants on HFOV. The MOR parameter helps in identifying effective lung recruitment in terms of gas exchange and detecting overdistention, offering potential to differentiate beneficial from harmful lung recruitment maneuvers. This study presents a practical EIT-based parameter to evaluate lung recruitment and overdistention, providing a precise complement to conventional oxygenation metrics. The findings could optimize ventilation strategies in extremely preterm infants, potentially reducing lung injury and improving survival without bronchopulmonary dysplasia.
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