ArticleClinical oral investigations2025
Evaluation of osteoconductivity and inflammatory response of a resin-based and a resin-free calcium silicate sealer: an in vivo study.
Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Cytotoxicity and Bioactivity of Five Hydraulic Silicate Cements in Human Dental Pulp Cells at Different Setting Stages.International dental journal · 2026Article
- Article
- Single cone versus carrier-based obturation using a premixed bioceramic sealer in postgraduate master cohort: a 36 months retrospective evaluation.Clinical oral investigations · 2026Article
- Nonsurgical Endodontic Retreatment of a Large Cyst-Like Periapical Lesion With Buccal and Palatal Cortical Plate Perforations and Maxillary Sinus Involvement: A 2-Year CBCT Follow-Up Case Report.Clinical case reports · 2026Article
- Randomized Trial of Bioceramic Apical Barrier Methods in Necrotic Immature Incisors: Effects on Pain, Extrusion, and Procedure Duration.Children (Basel, Switzerland) · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aimed to assess the biocompatibility and osteoconductivity of a resin-based and a resin-free calcium silicate sealer and their ability to promote healing of induced periapical lesions in mature dogs' teeth. MATERIALS AND
methodsPeriapical lesions were induced at 40 mandibular premolars of eight mongrel dogs. Following root canal preparation, the canals were obturated with a single cone and either TotalFill BC (n = 16) or MTA Fillapex (n = 16), while the positive control group (n = 8) remained unfilled. To ensure sealer extrusion during obturation, apical foramina were enlarged intentionally. Histological evaluations were conducted after one and four months, utilizing hematoxylin and eosin staining for inflammatory cell counts, Goldner's trichrome stain for new bone formation, and immunohistochemistry for osteopontin (OPN) expression. ImageJ software was used for quantitative analysis, and statistical comparisons were made using the Kruskal-Wallis and the Mann-Whitney U with Bonferroni's tests (p < 0.05).
resultsTotalFill BC Sealer induced a significantly lower inflammatory response than MTA Fillapex (p < 0.05). A significant reduction in inflammation was observed over time. TotalFill BC Sealer exhibited a significantly higher percentage of new bone formation and significantly higher OPN expression than MTA Fillapex and the positive control (p < 0.05). At four months, TotalFill BC Sealer showed enhanced bone formation with minimal residual inflammation, whereas MTA Fillapex demonstrated moderate healing with ongoing remodeling.
conclusionThe resin-free TotalFill BC Sealer exhibited superior biocompatibility, promoted faster inflammation resolution, and stimulated more new bone formation compared to the resin-based sealer MTA Fillapex when in direct contact with periapical tissues.
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