Evidence map›Paper›PMID 40467923›Full record

ArticleNature metabolism2025

State-dependent central synaptic regulation by GLP-1 is essential for energy homeostasis.

Le Wang, Rohan H Savani, Yi Lu, Matteo Bernabucci, Jorge Luis-Islas, Erin Park, Ishnoor Singh, Wei Xu, Abdelfattah El Ouaamari, Michael B Wheeler and 3 more

Abstract read
In one paragraph

Article in Nature metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Le WangCenter for NeuroMetabolism, The Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Rohan H SavaniCenter for NeuroMetabolism, The Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.ORCID http://orcid.org/0009-0001-2649-6572
Yi LuCenter for NeuroMetabolism, The Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Matteo BernabucciCenter for NeuroMetabolism, The Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.ORCID http://orcid.org/0000-0003-4458-117X
Jorge Luis-IslasCenter for NeuroMetabolism, The Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.ORCID http://orcid.org/0000-0002-9201-3321
Erin ParkCenter for NeuroMetabolism, The Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Ishnoor SinghCenter for NeuroMetabolism, The Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Wei XuDepartment of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-0987-2481
Abdelfattah El OuaamariDepartment of Cell Biology and Anatomy, New York Medical College, Valhalla, NY, USA.
Michael B WheelerDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
Harvey J GrillInstitute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-3290-3784
Mark A RossiCenter for NeuroMetabolism, The Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.ORCID http://orcid.org/0000-0002-5724-3615
Zhiping P PangCenter for NeuroMetabolism, The Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA. zhiping.pang@rutgers.edu.ORCID http://orcid.org/0000-0002-6183-1233

Funding

Deciphering the neural basis of alcohol use disorders using human and mouse neuronsR01AA023797 · NIAAA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ZHIPING P. PANG · 2016 to 2026
$4.8M
Synaptic and circuit mechanisms of central GLP-1 signaling in energy balanceR01DK131452 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ZHIPING P. PANG · 2022 to 2026
$2.4M
Developing genetically-encoded detectors for neuropeptide release based on class B G-protein coupled peptide receptorsRF1MH120144 · NIMH · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI PANG, ZHIPING P. · 2019 to 2019
$2.2M
Lateral Hypothalamic circuit dysfunction underlying the development of diet-induced obesityR01DK136641 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Mark Allen Rossi · 2023 to 2026
$1.7M
A multiphoton system that allows simultaneous multiphoton imaging and 3D optical stimulationS10MH124725 · NIMH · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI PANG, ZHIPING P. · 2021 to 2021
$600k
NIAAA NIH HHS R01 AA023797NIDDK NIH HHS R01 DK131452NIDDK NIH HHS R01 DK136641NIMH NIH HHS RF1 MH120144NIMH NIH HHS S10 MH124725Robert Wood Johnson Foundation (RWJF) 74260U.S. Department of Health Human Services | National Institutes of Health (NIH) R01DK131452U.S. Department of Health Human Services | NIH | National Institute of Mental Health (NIMH) RF1MH120144
6 · The paper itself

Abstract

Central glucagon-like peptide-1 (GLP-1), secreted by a distinct population of nucleus tractus solitarius neurons, suppresses feeding but the exact mechanisms of action in the brain remain unclear. Here, we investigate a descending circuit formed by GLP-1 receptor (GLP-1R) neurons in the paraventricular hypothalamic nucleus (PVN

Indexed as

Energy MetabolismGlucagon-Like Peptide 1HomeostasisSynapsesAnimalsBrain StemGlucagon-Like Peptide-1 ReceptorMaleMiceMice, Inbred C57BLNeuronsObesityParaventricular Hypothalamic NucleusGlucagon-Like Peptide 1Glucagon-Like Peptide-1 Receptor

Identifiers

PMID40467923
PMCPMC12967307

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.