ArticleNature neuroscience2025
Formation of an expanding memory representation in the hippocampus.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Instructive signals drive learning through behavioral timescale synaptic plasticity in the hippocampus and beyond.Current research in neurobiology · 2026Article
- Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Flexible navigation with neuromodulated cognitive maps.PLoS computational biology · 2026Article
- Behavioral timescale synaptic plasticity: properties, elements and functions.Nature neuroscience · 2026Review
- Learning-dependent feedback by OLM interneurons shapes CA1 representations.bioRxiv : the preprint server for biology · 2026Article
- Single-Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Unconstrained Plasticity Disrupts Memory Consolidation in a Mouse Model of Rett Syndrome.bioRxiv : the preprint server for biology · 2026Article
- The circuitry regulation of associative learning: dissociated and integrated function of the perirhinal cortex and hippocampus.Frontiers in neural circuits · 2026Review
- Gut dysbiosis impacts estrogen levels in APP/PS1 transgenic female mice.Gut microbes · 2025Article
- Slow synaptic plasticity from the hippocampus underlies gradual mapping and fragmentation of novel spaces by grid cells.bioRxiv : the preprint server for biology · 2025Article
- Behavioral Timescale Synaptic Plasticity: A Burst in the Field of Learning and Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Stability through plasticity: Finding robust memories through representational drift.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Hippocampal OLM interneurons regulate CA1 place cell plasticity and remapping.Nature communications · 2025Article
- Behavioral Timing of Interictal Spikes, But Not Rate, Correlates with Impaired Working Memory Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Diverse calcium dynamics underlie place field formation in hippocampal CA1 pyramidal cells.eLife · 2025Article
- Article
- Mechanisms of experience-dependent place-cell referencing in hippocampal area CA1.Nature neuroscience · 2025Article
- Formation of an expanding memory representation in the hippocampus.Nature neuroscience · 2025Article
- Brain-wide microstrokes affect the stability of memory circuits in the hippocampus.Nature communications · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How brain networks connected by labile synapses store new information without catastrophically overwriting previous memories remains poorly understood. To examine this, we tracked the same population of hippocampal CA1 place cells (PCs) as mice learned a task for 7 days. We found evidence of memory formation as both the number of PCs maintaining a stable place field and the stability of individual PCs progressively increased across the week until most of the representation was composed of long-term stable PCs. The stable PCs disproportionately represented task-related learned information, were retrieved earlier within a behavioral session and showed a strong correlation with behavioral performance. Both the initial formation of PCs and their retrieval on subsequent days were accompanied by prominent signs of behavioral timescale synaptic plasticity (BTSP), suggesting that even stable PCs were re-formed by synaptic plasticity each session. Further experimental evidence supported by a cascade-type state model indicates that CA1 PCs increase their stability each day they are active, eventually forming a highly stable population. The results suggest that CA1 memory is implemented by an increase in the likelihood of new neuron-specific synaptic plasticity, as opposed to extensive long-term synaptic weight stabilization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.