SynthesisScientific reports2025
Immediate and short-term effect of physical exercise on BDNF in multiple sclerosis patients: a systematic review and meta-analysis.
Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Physical exercise as a therapeutic strategy in animal models of Alzheimer's disease: Molecular, behavioral, and histopathological evidence.Biochemistry and biophysics reports · 2026Review
- Effects of Exercise Interventions on Peripheral Brain-Derived Neurotrophic Factor: An Umbrella Meta-Analysis Across Clinical and Healthy Populations.Journal of clinical medicine · 2026Review
- Exercise-Induced Metaplasticity: Breaking the Addiction Cycle in Methamphetamine Use Disorder.Sports medicine - open · 2026Review
- Exercise as Modulator of Brain-Derived Neurotrophic Factor in Adolescents: A Systematic Review of Randomized Controlled Trials.Sports (Basel, Switzerland) · 2025Review
- Exercise as Modulator of Brain-Derived Neurotrophic Factor (BDNF) in Children: A Systematic Review of Randomized Controlled Trials.Life (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Low brain-derived neurotrophic factor (BDNF) concentrations have been found in individuals with multiple sclerosis (MS). Physical exercise is an effective strategy for acutely increasing the levels of this neurotrophin in various populations; nevertheless, definitive results are still required for individuals with MS. Thus, this systematic review with meta-analysis aimed to analyze the acute and short-term effects of physical exercise on BDNF concentrations in MS patients. In this pre-registered systematic review (PROSPERO; ID: CRD42024505920), six electronic databases (PubMed-Medline, Scopus, Web of Science, SportDiscus, EbscoHost, and Cochrane) were searched by two independent researchers to identify eligible studies investigating the acute or short-term effects (≤ 3 weeks) of physical exercise sessions on blood concentration of BDNF in MS. Studies that used a sample population with other pathologies or did not provide or specify numerical data on the specified variables were excluded. After applying the inclusion and exclusion criteria, nine studies were included. A total sample of 259 people with MS were analyzed. Effect sizes of outcomes were presented as standardized mean difference (SMD) and 95% confidence intervals (95%CI). The effect estimation was computed using the inverse variance random effects method. Immediately after a session, a significant increase in BDNF was observed (large standardized mean difference (SMD) = 1.52, p = 0.001, I2 = 95). A significant effect (SMD = 0.27, p = 0.05; I
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.