Evidence map›Paper›PMID 40467756›Full record

ArticleScientific reports2025

Algorithm and ninhydrin method allow for measurement of the postprandial appearance of peptides in blood.

Stefan G Pierzynowski, Piotr Wychowański, Wiesław Szczesny, Robert Galloto, Kamil Zaworski, Dominika Szkopek, Jarosław Woliński, Janine Donaldson, Kateryna Pierzynowska

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stefan G PierzynowskiDepartment of Biology, Lund University, Lund, Sweden. stefan.pierzynowski@biol.lu.se.
Piotr WychowańskiDepartment of Head and Neck and Sensory Organs, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Gemelli Foundation for the University Policlinic, Catholic University of the "Sacred Heart", Rome, Italy. piotrwychowanski@wychowanski.pl.
Wiesław SzczesnyAnara AB, Trelleborg, Sweden.
Robert GallotoAnagram Therapeutics, Inc, Natick, MA, USA.
Kamil ZaworskiDepartment of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jabłonna, Poland.
Dominika SzkopekDepartment of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jabłonna, Poland.
Jarosław WolińskiDepartment of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jabłonna, Poland.
Janine DonaldsonAnara AB, Trelleborg, Sweden.
Kateryna PierzynowskaDepartment of Biology, Lund University, Lund, Sweden. Kateryna.Pierzynowska@biol.lu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recognition of amine groups by ninhydrin, along with a simple mathematical algorithm, showed that di- and tripeptides derived from dietary protein are the major end products of protein digestion entering the blood postprandially. There are thousands of oligopeptides appearing in the gut during protein digestion. However, the presented study on a pig model clearly shows that peptides longer than tri-amino acid peptides do not appear postprandially in the blood in nutritional amounts. We hypothesize that the measurement of postprandial free amino acids, di- and tripeptides and proportions between these components could be a useful, desirable tool both in laboratory and clinical practice, which could be used to determine the metabolic importance of protein digestion end products in health and disease.

Indexed as

AlgorithmsNinhydrinPeptidesPostprandial PeriodAnimalsDietary ProteinsSwineDietary ProteinsNinhydrinPeptidesAlgorithmDipeptidesMixed meal tolerance testProtein digestion end productsRevisited ninhydrin methodTripeptides

Identifiers

PMID40467756
PMCPMC12137680

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.