Evidence map›Paper›PMID 40467696›Full record

ArticleScientific reports2025

Serum neutrophil gelatinase associated Lipocalin as a novel biomarker for diagnosing acute pyelonephritis in adults.

Ayat Shaban Mousa ElNahal, Ali Ibrahim, Elsayed Abdelhalim, Sally Hassan Essawy, Ahmed Behiry, Mo'men Saadoun, Nahla Nosair, Hebatallah Abdelmaksoud Abdelmonsef, Hossam Nabeeh, Tarek Abdelbaky and 1 more

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ayat Shaban Mousa ElNahalMedical Microbiology Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, 33155, Egypt.
Ali IbrahimUrology Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, 33155, Egypt.ORCID http://orcid.org/0000-0001-5705-4251
Elsayed AbdelhalimUrology Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, 33155, Egypt. Sayedhalim20@kfs.edu.eg.ORCID http://orcid.org/0009-0000-1401-7629
Sally Hassan EssawyMedical Microbiology Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, 33155, Egypt.
Ahmed BehiryUrology Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, 33155, Egypt.
Mo'men SaadounClinical Pathology Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, 33155, Egypt.
Nahla NosairClinical Pathology Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, 33155, Egypt.
Hebatallah Abdelmaksoud AbdelmonsefCommunity medicine Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, 33155, Egypt.
Hossam NabeehUrology Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, 33155, Egypt.ORCID http://orcid.org/0000-0003-3611-1274
Tarek AbdelbakyUrology Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, 33155, Egypt.ORCID http://orcid.org/0000-0003-3019-9228
Diaa-Eldin TahaUrology Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, 33155, Egypt.ORCID http://orcid.org/0000-0003-3295-0505

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To assess the diagnostic value of serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) in adult patients with Acute Pyelonephritis. A total of 132 participants divided into two groups as 66 Hospitalized patients aged ≥ 20 years suspected of having acute pyelonephritis and 66 age and sex matched participants don't have pyelonephritis. Acute Pyelonephritis was diagnosed in patients with fever, chills or the costovertebral angle tenderness, and bacteriuria higher than 105 CFU/mL without any other focus of infection. No statistically significant differences were observed between the pyelonephritis and non-pyelonephritis groups regarding demographic data or comorbidities. However, the pyelonephritis group exhibited statistically significant differences in Serum NGAL levels, abnormal urine analysis findings, total leukocyte count, and serum C-reactive protein (CRP) levels, with p-values less than 0.001. This study aims to evaluate the potential of Serum NGAL as an early diagnostic biomarker for pyelonephritis, offering a promising tool for timely and accurate diagnosis.

Indexed as

Lipocalin-2PyelonephritisAcute DiseaseAdultAgedBiomarkersC-Reactive ProteinFemaleHumansMaleMiddle AgedBiomarkersC-Reactive ProteinLCN2 protein, humanLipocalin-2BiomarkerNeutrophil gelatinase-associated LipocalinPyelonephritisUrinary tract infection

Identifiers

PMID40467696
PMCPMC12137670

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.