ArticleNPJ Regenerative medicine2025
Spiny mice (Acomys) regenerate wounded whisker pad skin with whisker follicles, muscles, and targeted innervation.
Article in NPJ Regenerative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- What we can learn from hibernators and other adapted animals about organ transplantation: mechanisms of cold resistance and enhanced regeneration.Protein & cell · 2026Article
- The periodical formation of the vaginal closure membrane in guinea pigs is a regeneration process maintained by a special stem cell niche.Research square · 2026Article
- Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Human skin is repaired by scar formation, lacking hair follicles, arrector pili muscles, and targeted innervation. Scarring leads to significant losses in skin functionality. Contrary to humans, spiny mice (Acomys spp.) repair skin via scar-free regeneration, regrowing hair follicles and muscles. However, skin across the body is diverse, and whether Acomys can regenerate specialized skin remains unclear. Here, we report that Acomys regenerated whisker pad skin with whisker follicles (i.e., vibrissae), blood sinuses, sebaceous glands, skeletal muscles, and targeted innervation. In contrast, CD-1 mice (Mus) healed via scarring and poor innervation of the scar. While whisker pad skin regeneration in Acomys was remarkable, only 20% of whiskers regenerated on average, ranging from 0% to 75%. Regenerated axons were bundled in epineurial sheaths, targeting the regenerated whisker, with an average of 75% of the uninjured innervation. This expands our understanding of Acomys skin regeneration and provides novel models for skin regeneration and sensorimotor recovery.
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Registered trials
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