ArticleScientific reports2025
Higher AJCC stage at primary tumor diagnosis may predict shorter survival in metastatic uveal melanoma.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Long-Term Local Control and Mortality After Transpupillary Thermotherapy of Small Uveal Melanomas.Clinical & experimental ophthalmology · 2026Article
- Characteristics and Outcomes of Patients with Early or Late Uveal Melanoma Metastasis: A Review.Ocular oncology and pathology · 2026Review
- Metastatic potential of small posterior uveal melanomas.Acta ophthalmologica · 2026Article
- Independent validation of time to treatment as a prognostic factor in uveal melanoma.BMC cancer · 2026Article
- Twelve reasons delays in uveal melanoma treatment might affect prognosis.The British journal of ophthalmology · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
In this international collaboration, we examined whether survival in metastatic uveal melanoma is associated with primary tumor size at initial diagnosis. A total of 128 and 205 patients with American Joint Committee on Cancer (AJCC) stage IV disease were included from the Netherlands and Sweden, respectively. Across both cohorts, patients whose tumors had a largest basal diameter ≥ 16 mm or a higher AJCC stage presented with a greater number of hepatic metastases and showed shorter Kaplan-Meier overall survival from the time of metastatic detection. However, this association did not persist after adjustment for the number of hepatic metastases in multivariate Cox regression and a Markov multi-state model. These findings suggest that primary tumor size is associated with survival in metastatic disease and the burden of metastatic lesions at detection, indicating a potential survival benefit of primary tumor treatment. Nevertheless, caution is warranted when interpreting these results, as they differ from some previous reports.
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