Evidence map›Paper›PMID 40467616›Full record

ArticleNature communications2025

Androgens inhibit protective CD8

Caroline J Duncombe, Nilasha Sen, Felicia N Watson, Alen S Poehlman, Erik D Layton, Kenneth Boey, Ethan N Conrad, Anya C Kalata, A Mariko Seilie, Kimberly A Dill-McFarland and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Caroline J DuncombeGraduate Program in Pathobiology, Department of Global Health, University of Washington, Seattle, WA, 98195, USA.ORCID http://orcid.org/0000-0002-4356-6317
Nilasha SenDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA.
Felicia N WatsonGraduate Program in Pathobiology, Department of Global Health, University of Washington, Seattle, WA, 98195, USA.ORCID http://orcid.org/0000-0003-1468-5648
Alen S PoehlmanDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA.
Erik D LaytonCenter for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0001-6409-290X
Kenneth BoeyDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA.ORCID http://orcid.org/0000-0002-6329-2333
Ethan N ConradDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA.
Anya C KalataDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA.
A Mariko SeilieDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA.
Kimberly A Dill-McFarlandCenter for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0003-1481-7065
Chetan SeshadriCenter for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, WA, 98109, USA.ORCID http://orcid.org/0000-0003-2783-7540
Melanie J ShearsDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA.ORCID http://orcid.org/0000-0002-8226-4354
Sean C MurphyGraduate Program in Pathobiology, Department of Global Health, University of Washington, Seattle, WA, 98195, USA. murphysc@uw.edu.ORCID http://orcid.org/0000-0002-2048-0131

Funding

cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Liver resident memory for malariaR01AI141857 · NIAID · UNIVERSITY OF WASHINGTON · PI MURPHY, SEAN C · 2019 to 2023
$3.9M
National Science Foundation (NSF) 1000341692NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIAID NIH HHS R01 AI141857NIDA NIH HHS 75N95020D00005ORFDO NIH HHS 75N99020D00005
6 · The paper itself

Abstract

Attenuated whole organism vaccines targeting the malaria liver stage reliably confer sterile immunity. These vaccines completely protect female mice from infection, but protection in male mice remains unproven. We discover that male mice vaccinated with prime-and-trap, a whole organism-based vaccine strategy, exhibit poorer protection against Plasmodium sporozoite challenge than females. We investigate this sex difference, and identify vaccinated males have fewer hepatic memory CD8

Indexed as

AndrogensCD8-Positive T-LymphocytesMalariaMalaria VaccinesAnimalsFemaleImmunologic MemoryLiverMaleMiceMice, Inbred C57BLPlasmodium bergheiSporozoitesVaccinationAndrogensMalaria Vaccines

Identifiers

PMID40467616
PMCPMC12137616

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.