Evidence map›Paper›PMID 40467615›Full record

ArticleScientific reports2025

Development of a biodegradable α-TCP/PLA/nMgO composite for enhanced guided bone regeneration.

Wenbo Du, Xueqi Guo, Qiubei Zheng, Liping Wang, Hanfu Su

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenbo Du *Department of Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China.
Xueqi Guo *Department of Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China.
Qiubei ZhengDepartment of Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China.
Liping WangDepartment of Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China. wangliplj@126.com.
Hanfu SuDepartment of Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China. hanfusu@gzhmu.edu.cn.

Funding

Scientific Research Projects for Oral Implantology of China Oral Health Foundation COHF ZZZX202403
6 · The paper itself

Abstract

Creating and maintaining a stable osteogenic space is crucial for successful guided bone regeneration (GBR). This study aimed to develop a customizable composite material with a moderate degradation rate that provides sustained spatial support for GBR. An in situ embedding-reinforced strategy was proposed to develop a composite material consisting of alpha-tricalcium phosphate (α-TCP), polylactic acid (PLA), and nano-magnesium oxide (nMgO). The surface characteristics, thermal stability, strength, and hardness of the composites were tested. Biocompatibility, osteogenesis, and degradation rate were evaluated both in vitro and in vivo. Compared to PLA alone, the α-TCP/PLA/nMgO composite exhibited a fivefold increase in bending strength, surpassing 95.75 MPa, along with an improvement in surface hardness from 22.8 HV1 to 28.73 HV1. In vitro experiments demonstrated that α-TCP/PLA/nMgO exhibited minimal cell cytotoxicity, promoted excellent cell adhesion, and substantial induced osteogenesis in bone marrow mesenchymal stem cells (BMSCs). In vivo experiments in mice confirmed that α-TCP/PLA/nMgO displayed excellent biocompatibility comparable to antigen-extracted xenografts and had a moderate degradation rate that provided sustained spatial support. Importantly, the α-TCP/PLA/nMgO composite can be manufactured into personalized spatial supporting meshes in accordance with individual bone defects using CAD/CAM technology, making it a promising solution for precise guided bone regeneration in scenarios where addition supporting apparatus is needed.

Indexed as

Biocompatible MaterialsBone RegenerationCalcium PhosphatesGuided Tissue RegenerationMagnesium OxidePolyestersAnimalsCell AdhesionHumansMesenchymal Stem CellsMiceOsteogenesisTissue Scaffoldsalpha-tricalcium phosphateBiocompatible MaterialsCalcium PhosphatesMagnesium OxidePolyesterspoly(lactide)AbsorbableComposite materialCustomizableGuided bone regenerationPrecise medicine

Identifiers

PMID40467615
PMCPMC12137624

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.