Evidence map›Paper›PMID 40467579›Full record

ArticleNPJ Parkinson's disease2025

New diagnostic and staging framework applied to established PD in the BioFIND cohort.

Marco J Russo, Un Jung Kang, BioFIND Study

Abstract read
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Marco J RussoMovement Disorders Division, Department of Neurology, Rutgers University, Robert Wood Johnson Medical School, New Brunswick, NJ, USA. marco.russo@rutgers.edu.
Un Jung KangThe Marlene and Paolo Fresco Institute for Parkinson's & Movement Disorders, Department of Neurology, Department of Neuroscience and Physiology, Neuroscience Institute, The Parekh Center for Interdisciplinary Neurology, NYU Grossman School of Medicine, New York, NY, USA.
BioFIND Study

Funding

Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3U01NS113851 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniel M. Corcos · 2019 to 2026
$29.6M
Clinical Trial Readiness for Multiple System Atrophy - Resubmission - 1U01NS122419 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HORACIO KAUFMANN · 2022 to 2026
$4.8M
Early Onset Parkinson’s disease subtypes and pathogenic mechanismsR01NS133742 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Giulietta Maria Riboldi · 2023 to 2026
$2.7M
Biomarkers for parkinsonian disorders in CNS-originating extracellular vesiclesRF1NS126406 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BITAN, GAL · 2023 to 2024
$2.6M
Single Cell Transcriptomic Profiling of Multiple System Atrophy BrainR01NS131658 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Un Jung Kang · 2024 to 2026
$2.0M
NIH HHS R01 NS131658, U01 NS113851, U01 NS122419, RF1 NS126406, R01 NS133742NINDS NIH HHS R01 NS131658NINDS NIH HHS R01 NS133742NINDS NIH HHS RF1 NS126406NINDS NIH HHS U01 NS113851NINDS NIH HHS U01 NS122419
6 · The paper itself

Abstract

The proposed Neuronal α-Synuclein Disease Integrated Staging System (NSD-ISS) was recently applied to early Parkinson's disease (PD) cohorts. We applied this research framework to the BioFIND study cohort, which includes more moderately advanced PD participants with clinically established PD. Disease durations within each ISS stage were highly variable. Cognitive and non-motor anchors had little weight in determining staging. The analysis highlights strengths and limitations of NSD-ISS to guide further refinement of an integrated staging system.

Identifiers

PMID40467579
PMCPMC12137746

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.