Evidence map›Paper›PMID 40467528›Full record

ArticleImmunology2025

Neutrophils in the Bone Marrow Express DEC205, Guiding Their Migration to Inflamed Tissues.

Shiying Jin, Xuan Lei, Sonali Singh, Alexander Enk, Karsten Mahnke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shiying JinDepartment of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.
Xuan LeiDepartment of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.ORCID 0000-0002-5240-0925
Sonali SinghDepartment of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.
Alexander EnkDepartment of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.
Karsten MahnkeDepartment of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.ORCID 0000-0003-3449-1365

Funding

China Scholarship Council 202006090016China Scholarship Council 202208320096Deutsche Forschungsgemeinschaft CRC156 B3Deutsche Forschungsgemeinschaft MA 1924/9-1
6 · The paper itself

Abstract

The surface molecule DEC205 (CD205) is well-characterised in murine dendritic cells (DCs) as an antigen uptake receptor. However, recent studies have also identified its expression in other leukocytes, including B cells and neutrophils. In B cells, DEC205 functions as an endocytic receptor, similar to its role in DCs. Since neutrophils are not professional antigen-presenting cells, we sought to investigate the functions of DEC205 beyond endocytosis. Analysis of cell surface expression of DEC205 in neutrophils at different maturation stages and anatomical locations revealed its downregulation upon in vitro activation and during tissue infiltration, such as in skin inflammation and thioglycolate-induced peritonitis. In DEC205-deficient (DEC205

Indexed as

Antigens, CDBone MarrowBone Marrow CellsCell MovementInflammationLectins, C-TypeNeutrophilsPeritonitisReceptors, Cell SurfaceAnimalsCell AdhesionDendritic CellsMiceMice, Inbred C57BLMice, KnockoutMinor Histocompatibility AntigensAntigens, CDDEC-205 receptorLectins, C-TypeMinor Histocompatibility AntigensReceptors, Cell Surfaceadhesion moleculescell surface moleculescell traffickinginflammationneutrophils

Identifiers

PMID40467528
PMCPMC12401796

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.