Evidence map›Paper›PMID 40467503›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Exogenous Lipoid Pneumonia Induced by the Excessive Use of Menthol-containing Nasal Inhalers and Subsequent Acute Hypersensitivity Pneumonia Triggered by Domestic Environmental Antigens.

Yuki Fukushiro, Yasushi Horimasu, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Takeshi Masuda, Taku Nakashima, Hiroshi Iwamoto, Shinichiro Ohshimo, Kazunori Fujitaka, Noboru Hattori

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuki FukushiroDepartment of Respiratory Medicine, Hiroshima University Hospital, Japan.
Yasushi HorimasuDepartment of Respiratory Medicine, Hiroshima University Hospital, Japan.
Kakuhiro YamaguchiDepartment of Respiratory Medicine, Hiroshima University Hospital, Japan.
Shinjiro SakamotoDepartment of Respiratory Medicine, Hiroshima University Hospital, Japan.
Takeshi MasudaDepartment of Respiratory Medicine, Hiroshima University Hospital, Japan.
Taku NakashimaDepartment of Respiratory Medicine, Hiroshima University Hospital, Japan.
Hiroshi IwamotoDepartment of Respiratory Medicine, Hiroshima University Hospital, Japan.
Shinichiro OhshimoDepartment of Emergency and Critical Care Medicine, Hiroshima University Hospital, Japan.
Kazunori FujitakaDepartment of Respiratory Medicine, Hiroshima University Hospital, Japan.
Noboru HattoriDepartment of Respiratory Medicine, Hiroshima University Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 58-year-old Japanese man presented at our hospital with respiratory failure. Computed tomography (CT) revealed scattered fat-attenuated consolidations, and bronchoalveolar lavage fluid (BALF) showed neutrophilia, leading to a diagnosis of exogenous lipoid pneumonia (ELP) caused by the excessive use of a menthol-containing nasal inhaler. Despite a temporary improvement, the patient experienced recurrent respiratory failure shortly after discharge. CT revealed centrilobular ground-glass opacities, and a bronchoalveolar BALF analysis revealed lymphocytosis, suggesting acute hypersensitivity pneumonitis (AHP) triggered by domestic environmental antigens. Antigen avoidance was successful and remission was maintained. The rare sequential occurrence of AHP following ELP suggests a potential pathophysiological connection between these conditions.

Indexed as

Alveolitis, Extrinsic AllergicAntigensMentholNebulizers and VaporizersPneumonia, LipidAcute DiseaseHumansMaleMiddle AgedAntigensMentholexogenous lipoid pneumoniafoamy macrophageshypersensitivity pneumoniainflammasomeNOD-like receptor family member pyrin domain-containing protein 3

Identifiers

PMID40467503
PMCPMC12740410

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.