Evidence map›Paper›PMID 40467501›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Two Cases of Mixed Neuroendocrine Non-neuroendcrine Cell Neoplasms (MiNENs) of the Pancreas with Notable Molecular Pathological Features.

Satomi Saito, Yukiko Takayama, Mariko Tanaka, Nao Otsuka, Junichi Akao, Junko Tahara, Masataka Kikuyama, Katsutoshi Tokushige, Taito Itoh, Toru Furukawa and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Satomi SaitoInstitute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University, Japan.
Yukiko TakayamaInstitute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University, Japan.
Mariko TanakaInstitute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University, Japan.
Nao OtsukaInstitute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University, Japan.
Junichi AkaoInstitute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University, Japan.
Junko TaharaInstitute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University, Japan.
Masataka KikuyamaInstitute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University, Japan.
Katsutoshi TokushigeInstitute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University, Japan.
Taito ItohDepartment of Investigative Pathology, Tohoku University Graduate School of Medicine, Japan.
Toru FurukawaDepartment of Investigative Pathology, Tohoku University Graduate School of Medicine, Japan.
Ryota HiguchiDivision of Gastroenterological Surgery, Tokyo Women's Medical University Yachiyo Medical Center, Japan.
Takehisa YazawaDepartment of Gastroenterological Surgery, Utsunomiya Memorial Hospital, Japan.
Kyoko ShimizuShinjuku Mitsui Building Clinic, Sakakibara Kouseikai, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report two cases of pancreatic mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs). Case A was a mixed ductal-neuroendocrine cell carcinoma with a KRAS mutation and loss of RB1 and SMAD4 expression. Case B was a mixed acinar-neuroendocrine cell carcinoma with wild-type KRAS and loss of p16 and SMAD4 expression. The expression of RB1 and ARID1A was also reduced. These results support the recently proposed classification of neuroendocrine carcinoma into ductal and acinar types based on molecular features, which may facilitate the understanding and development of specific treatments for this intractable tumor.

Indexed as

Carcinoma, NeuroendocrinePancreatic NeoplasmsDNA-Binding ProteinsHumansMutationNuclear ProteinsProto-Oncogene Proteins p21(ras)Retinoblastoma Binding ProteinsSmad4 ProteinTranscription FactorsUbiquitin-Protein LigasesARID1A protein, humanDNA-Binding ProteinsKRAS protein, humanNuclear ProteinsProto-Oncogene Proteins p21(ras)RB1 protein, humanRetinoblastoma Binding ProteinsSmad4 ProteinSMAD4 protein, humanTranscription FactorsUbiquitin-Protein LigasesMANECMiNENmixed acinar-neuroendocrine cell carcinomamixed adenoneuroendocrine carcinomamixed neuroendocrine non-neuroendocrine neoplasmpancreatic NEC

Identifiers

PMID40467501
PMCPMC12740392

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.