Evidence map›Paper›PMID 40467329›Full record

Trial reportThorax2025

Circulating miRNAs and childhood asthma ICS response: a stratified analysis in the intervention arm of an RCT with vitamin D effect modification.

Mingye Jiang, Yunxiao Zhang, Tao Liu, Xiaoning Hong, Alvin T Kho, Jiang Li, Yunfei Gao, Rinku Sharma, Juan Carlos Celedon, Michael McGeachie and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Thorax, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mingye Jiang *Clinical Big Data Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.ORCID 0009-0004-2522-4446
Yunxiao Zhang *Clinical Big Data Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.ORCID 0000-0001-5968-7319
Tao Liu *State Key Laboratory of Respiratory Disease, Joint International Research Laboratory of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Xiaoning Hong *Clinical Big Data Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.ORCID 0000-0001-8375-6572
Alvin T KhoComputational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-9887-312X
Jiang LiClinical Big Data Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.
Yunfei GaoDepartment of Otolaryngology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China.
Rinku SharmaChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Juan Carlos CeledonDivision of Pulmonary Medicine, Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-6139-5320
Michael McGeachieChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Scott WeissChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Kelan G TantisiraChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA lijiang29@mail.sysu.edu.cn ktantisira@health.ucsd.edu.
Jiang LiClinical Big Data Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China lijiang29@mail.sysu.edu.cn ktantisira@health.ucsd.edu.

Funding

Asthma Exacerbations and MicroRNA prediction: Treatment Response in an Underserved Ethnicity (AEM-TRUE)R01HL139634 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MCGEACHIE, MICHAEL JOHN · 2018 to 2022
$4.3M
MICRORNAS IN CIRCULATION: ONTOLOGIES OF ASTHMA SEVERITY AND TREATMENT (MICROCOAST)R01HL127332 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2015 to 2018
$3.4M
Genomics and Pharmacogenomics of Symptoms in AsthmaR01HL162570 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TANTISIRA, KELAN G · 2021 to 2024
$2.9M
DISEASE AND HEALTH: ASTHMA RESILIENCE THROUGH MICRORNA ATTRIBUTES (DHARMA)R01HL129935 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2015 to 2017
$1.4M
NHLBI NIH HHS R01 HL127332NHLBI NIH HHS R01 HL129935NHLBI NIH HHS R01 HL139634NHLBI NIH HHS R01 HL162570
6 · The paper itself

Abstract

backgroundmiRNAs play a crucial role in the anti-inflammatory effects of inhaled corticosteroids (ICS) in asthma. Vitamin D can modulate the expression of several miRNAs and reduces asthma exacerbations, but its molecular interaction with ICS remains unclear.

objectiveWe hypothesised that vitamin D influences long-term ICS response through miRNA regulation.

methodsBaseline serum miRNAs were sequenced from 462 subjects in the Childhood Asthma Management Program (CAMP), with 187 randomised to ICS treatment included in this study. Linear regression assessed associations between miRNA expression and prebronchodilator forced expiratory volume in 1 s per cent predicted (FEV

results12 miRNAs were significantly associated with ICS-mediated FEV

conclusionsVitamin D may modulate ICS response through miRNAs involved in immune cell differentiation, which could serve as biomarkers for ICS response, particularly in vitamin D insufficient individuals.

Indexed as

Adrenal Cortex HormonesAsthmaCirculating MicroRNAMicroRNAsVitamin DAdministration, InhalationChildDexamethasoneFemaleForced Expiratory VolumeGlucocorticoidsHumansMaleAdrenal Cortex HormonesCirculating MicroRNADexamethasoneGlucocorticoidsMicroRNAsVitamin DAsthmaAsthma MechanismsChildPaediatric asthma

Identifiers

PMID40467329
PMCPMC12353034

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.