Evidence map›Paper›PMID 40467301›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Atypical Retinal Ganglion Cell Function in a Mouse Model of Fragile X Syndrome.

Anna L Vlasits, Maria Syeda, Annelise Wickman, Elias Laskey, Pedro Guzman, Tiffany M Schmidt

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Altered Primary Somatosensory Neuron Development in a Pten Heterozygous Model for Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Anna L VlasitsDepartment of Neurobiology, Northwestern University, Evanston, Illinois 60208 avlasits@uic.edu.ORCID 0000-0002-4248-968X
Maria SyedaDepartment of Neurobiology, Northwestern University, Evanston, Illinois 60208.
Annelise WickmanDepartment of Neurobiology, Northwestern University, Evanston, Illinois 60208.
Elias LaskeyDepartment of Ophthalmology, University of Illinois, Chicago, Illinois 60608.
Pedro GuzmanDepartment of Neurobiology, Northwestern University, Evanston, Illinois 60208.
Tiffany M SchmidtDepartment of Neurobiology, Northwestern University, Evanston, Illinois 60208.ORCID 0000-0002-4791-6775

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SHUKLA, DEEPAK · 1985 to 2025
$14.8M
TRAINING GRANT IN SLEEP RESEARCHT32HL007909 · NHLBI · NORTHWESTERN UNIVERSITY · PI FRED W TUREK, Phyllis C. Zee · 1998 to 2026
$9.2M
Non-canonical GABAergic Pathways in the Visual SystemR01EY030565 · NEI · NORTHWESTERN UNIVERSITY · PI SCHMIDT, TIFFANY M. · 2020 to 2024
$2.6M
NEI NIH HHS P30 EY001792NEI NIH HHS R01 EY030565NHLBI NIH HHS T32 HL007909
6 · The paper itself

Abstract

The altered function of peripheral sensory neurons is an emerging mechanism for symptoms of autism spectrum disorders. Visual sensitivities are common in autism, but whether differences in the retina might underlie these sensitivities is not well understood. This includes fragile X syndrome (FXS), which is the most common syndromic cause of autism. We explored retinal function in the

Indexed as

Fragile X SyndromeRetinal Ganglion CellsAnimalsDendritesDisease Models, AnimalFragile X Messenger Ribonucleoprotein 1MaleMiceMice, Inbred C57BLMice, KnockoutPhotic StimulationFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1autismfragile X syndromeneurodevelopmental disorderretinaretinal ganglion cellvision

Identifiers

PMID40467301
PMCPMC12225599

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.