Trial reportJournal of clinical periodontology2025
Clinical and Patient-Reported Outcomes in Grade III Furcations: A Randomized Feasibility Trial With SMART Design.
Trial report in Journal of clinical periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Progression of Furcation Involvement: A Multi-Center Cohort Study of Incidence, Timing, and Risk Factors.Journal of periodontal research · 2026Article
- From empirical practice to precision medicine: developing a methodology for adjusting traditional Chinese medicine formula dosages based on eight multicenter clinical studies.Frontiers in pharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess the feasibility of applying sequential, multiple assignment, randomized trial (SMART) design in periodontology and to assess the response of grade III furcation-involved molars to various treatments.
methodsA member of the public served as a co-investigator. Twenty participants with at least one grade III furcation-involved molar tooth were randomized to either non-surgical periodontal treatment (NSPT) or open-flap debridement (OFD). They were reassessed 6 months later, where 'successful response' to therapy was defined with a 'combined outcome' incorporating patient-reported and clinical parameters. Based on SMART principles, non-responders underwent further treatment and were followed up to 12 months.
resultsAll study feasibility criteria were met, except 'planned recruitment rate', which was slower than expected. At the 6-month review, those who underwent OFD showed a greater reduction in probing pocket depth (PPD) compared to those who received NSPT (p = < 0.01). 'Success' was reached by 6 out of 10 NSPT participants and by 7 out of 10 OFD participants. Non-responders were further randomized and followed up to 12 months.
conclusionThis SMART design is feasible in periodontology trials. This study demonstrates its advantages and limitations along with clinical and patient-reported data of grade III furcations treated surgically or non-surgically.
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