ArticleJournal of advanced research2026
Single-nucleus RNA sequencing reveals Cntnap2
Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Central Sympathetic Nerve Activation-Mediated Hypertension: Target Mechanisms and Multimodal Interventions-From Basic Research to Clinical Translation.International journal of molecular sciences · 2026Review
- Placental exosomal miR-372-3p drives preeclampsia progression by inducing mitochondrial damage in RVLM neurons.Cellular & molecular biology letters · 2026Article
- Spatial transcriptomics of glioblastoma defines biologically and clinically significant reprogramming patterns across unique spatial microenvironments.bioRxiv : the preprint server for biology · 2025Article
- Cardiovascular disease and depression: a bidirectional relationship and its clinical implications.Frontiers in psychiatry · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe rostral ventrolateral medulla (RVLM) is a vital vasomotor nucleus involved in hypertension control. However, the molecular intricacies within RVLM cells, particularly in non-neuronal cell populations such as astrocytes, under hypertensive conditions remain to be systematically investigated.
objectivesWe aimed to elucidate cellular heterogeneity in the RVLM at single-cell resolution, with a focus on astrocytes, to further characterize its role in hypertension.
methodsTranscriptional changes in cells in the RVLM after hypertension were examined by using single-nucleus RNA sequencing (snRNA-seq). Further experiments, like radiotelemetry and immunofluorescence assays, were conducted to support the findings of snRNA-seq.
resultsIn total, 36 982 high-quality nuclei were obtained, with identification of nine cell types. Three transcriptomically distinct subtypes of astrocytes were defined within the astrocyte cell population: Cntnap2
conclusionOur findings suggest that Cntnap2 may impede glutamate homeostasis at least partially through regulating Eaat2 in astrocytes, which could consequently enhance RVLM neuronal excitability, increase sympathetic tone, and contribute to elevated BP.
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Registered trials
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