ArticleJournal of advanced research2026
Association of hematopoietic loss of Y chromosome with valvular heart disease incidence and sex susceptibility.
Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Mosaic Loss of Chromosome Y, Smoking, and Risk of Symptomatic Peripheral Artery Disease: Insights From a Longitudinal Cohort Study.Journal of the American Heart Association · 2026Article
- Mosaic Loss-of-Y Chromosome in Men Is Associated With Aortic Enlargement But Not Aortic Stenosis.JACC. Advances · 2026Article
- Cellular Senescence, Inflammaging and Cardiovascular Disease.Immunological reviews · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHematopoietic mosaic Loss Of Y chromosome (LOY), a condition referring to the age-related loss of Y chromosome in a subset of blood cells, is associated with shortened life expectancy and increased risk of age-related diseases in men. Despite Valvular Heart Disease (VHD) becoming more prevalent with aging, the underlying risk factors and mechanisms leading to sex-related differences in VHD remain unclear.
objectivesWe aimed to investigate the association between hematopoietic LOY and incident VHD, and to assess whether LOY contributes to sex disparities in VHD.
methodsWe analysed UK Biobank participants aged ≥ 60 without prevalent VHD. The primary outcome was incident VHD, and the secondary outcomes were incident degenerative Aortic Stenosis (AS) and Mitral Regurgitation (MR). Associations between LOY and the outcomes were assessed using multivariate-adjusted Cox regression, estimating Hazard Ratios (HR) and 95 % confidence intervals (CI).
resultsAmong 90,123 male participants, 606 (0.7 %) had LOY ≥ 40 %. Over a median follow-up of 14.1 years, a total of 7,663 VHD, 2,439 AS, and 1,997 MR cases were recorded. LOY ≥ 40 % was significantly associated with VHD (HR: 1.31, 95 % CI: 1.04-1.65), AS (HR: 1.47, 95 % CI: 1.00-2.15), and MR (HR: 1.69, 95 % CI: 1.12-2.55). Furthermore, male participants with LOY ≥ 40 % had significantly higher risk of VHD (HR: 1.93, 95 % CI: 1.47-2.51), AS (HR: 2.39, 95 % CI: 1.52-3.78) and MR (HR: 2.03, 95 % CI: 1.23-3.34) compared to matched females.
conclusionsMosaic LOY is independently associated with increased risk of incident VHD and contributes to the observed sex differences in VHD susceptibility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.