ArticleCell genomics2025
Depletion of aneuploid cells is shaped by cell-to-cell interactions.
Article in Cell genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Dual contributions of Xrp1 to genome integrity through the DNA damage response and cell competition.PLoS genetics · 2026Article
- A tumour-host feed-forward loop contributes to the growth of chromosomal instability-induced tumours.EMBO reports · 2026Article
- Impact of Chromosomal Instability and Aneuploidy in Cancer Development.Annual review of cancer biology · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aneuploidy is pervasive in early human embryos but robustly dampened during development. Later in life, aneuploidy correlates with pathological conditions, including cancer. Identification of the mechanisms underlying the elimination of aneuploid cells is relevant in development and disease. We characterized the impact on cell proliferation and survival of a large collection of molecularly defined segmental monosomies and trisomies of different sizes and ranges of overlap. Our data reveal signs of outcompetition of cells carrying small monosomies in regions devoid of previously known haploinsufficient genes. Dose-dependent effects of single genes or a discrete number of genes contribute to the phenomenon of cell competition through different mechanisms. By simultaneously inducing cells carrying monosomies and trisomies of the same genomic location, we show that trisomies potentiate or alleviate the negative effects of monosomy on growth, thus revealing a key role of cell interactions in defining the in vivo elimination of aneuploid cells.
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Registered trials
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