Evidence map›Paper›PMID 40466039›Full record

Observational studyCritical care explorations2025

Retrospective Analysis of a Multicenter Observational Study of the Relationship Between Social Determinants of Health and Complications After Children's Heart Surgery.

Khurram Mustafa, Christopher Leahy, Deborah Ridout, Katherine L Brown

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Critical care explorations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Khurram MustafaPaediatric Critical Care Unit, Leeds Children's Hospital, Leeds, United Kingdom.ORCID 0000-0002-1387-3201
Christopher LeahyPICANet, Child Health Outcomes Research at Leeds (CHORAL ), Leeds Institute for Data Analytics, School of Medicine, University of Leeds, Leeds, UK.
Deborah RidoutPopulation, Policy and Practice Research and Teaching Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
Katherine L BrownPaediatric Critical Care Unit, Leeds Children's Hospital, Leeds, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

importanceEpidemiological studies have highlighted disparities in illnesses and outcomes for critically unwell children.

objectivesWe aimed to describe social characteristics and explore links with the outcome of postoperative complications with children's heart surgery. DESIGN, SETTING, AND

participantsRetrospective analysis of a multicenter observational dataset including those under 17 years old undergoing heart surgery from October 2015 to June 2017 at five U.K. children's cardiac centers. MAIN OUTCOMES AND MEASURES: Univariate and multivariable multinomial regression analyses were undertaken for the outcome of predefined postoperative complications.

resultsOf 2898 cases meeting criteria, 2708 had complete data. Two thousand one hundred three (77.66%) had no complications, 369 (13.62%) had a single complication, 56 (2.06%) received Extracorporeal Life Support, and 179 (6.61%) had multiple complications. Children residing in low deprivation neighborhoods were under-represented: lowest quintile 361 (13.33%). Minoritized ethnic group was strongly linked to indices of deprivation: residence in neighborhoods with highest deprivation occurred with Bangladeshi, Black African, and Pakistani ethnicity and lowest deprivation with White ethnicities. Adjusted for clinical risk factors compared with the reference group (White), patients from Asian background had a significantly higher risk of developing single vs. no complications (odds ratio [OR], 1.53; 95% CI, 1.00-2.32) and Black patients had a higher risk of developing multiple vs. no complications (OR, 2.19; 95% CI, 1.09-4.41). Among single complications, Asian children had a higher risk of developing feeding issues (OR, 2.07; 95% CI, 1.13-3.28). CONCLUSIONS AND RELEVANCE: Ethnicity and socioeconomic deprivation may be linked to greater risk of certain complications after pediatric cardiac surgery. Further exploration of inequities is needed in this population.

Indexed as

Cardiac Surgical ProceduresPostoperative ComplicationsSocial Determinants of HealthAdolescentChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleRetrospective StudiesRisk FactorsSocioeconomic Factorscardiac surgerycomplicationsethnicityhealth inequalitiespediatricsocioeconomic

Identifiers

PMID40466039
PMCPMC12140732

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.