ArticleDental press journal of orthodontics2025
Cleaning solutions for orthodontic clear aligners: a microbiological and colorimetric analysis.
Article in Dental press journal of orthodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ageing effects on chemical, physical, mechanical, and morphological properties of clear aligners - a systematic review.Progress in orthodontics · 2026Pooled it
- BLIS M18 probiotic cleanser: effects on color and surface properties of conventional, milled, and 3D-printed PMMA.BMC oral health · 2026Article
- Effects of cleaning methods on the removal efficacy of Streptococcus mutans biofilm and material properties of thermoplastic aligner materials.BMC oral health · 2026Article
- Spectrophotometric, Periodontal and Subjective Evaluations on Five Different Products for Clear Aligners Cleansing: Randomised Clinical Trial.International journal of dentistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis in-vitro study aimed to evaluate the antibacterial efficacy and color changes induced by different chemical agents on the orthodontic aligners.
methodsThe sample consisted of Invisalign® aligners materials and seven solutions were tested: sodium hypochlorite (HYP), sodium bicarbonate (BIC), neutral detergent (DET), chlorhexidine gluconate (CX), white vinegar (VIN) diluted in water (1:3), Corega Tabs® effervescent tablets (COR), and distilled water (DW, control group). The microbiological control was evaluated by analyzing cell proliferation (CFU/ml) and cell metabolism (AlamarBlue® test), and the VITA EasyShade® Advance spectrophotometer was used for color change analysis, using multiple Mann-Whitney tests.
resultsAll solutions significantly reduced S. mutans biofilm (CFU/mL), except for the control group. The AlamarBlue® analysis showed a significant reduction in cell viability, except for the BIC solution (p=0.183). After 7 days, HYP showed significant color variation, compared to all the other solutions, except for the control group (p=0.095). After 14 days, BIC and CX showed significantly greater color variation than the control group (p=0.007). DET showed a large difference compared to BIC and CX (p=0.007), and a statistically significant difference compared to VIN and COR (p=0.015).
conclusionThe disinfectant solutions HYP, DET, CX, VIN, and COR significantly reduced the bacterial colonies of S. mutans and cellular metabolism. In addition, HYP, BIC, CX, and COR significantly affected the material color.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.