ArticleSao Paulo medical journal = Revista paulista de medicina2025
Effect of heat therapy compared with strength training on metabolic profile, heat shock response, inflammation, cardiovascular responses and microbiota in individuals with type 2 diabetes: study protocol of a randomized trial.
Article in Sao Paulo medical journal = Revista paulista de medicina, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05847075 (Effect of Heat Therapy Compared With Strength Training on Metabolic Profile, Heat Shock Response, Inflammation, Cardiovascular Responses and Microbiota in Individuals With Type 2 Diabetes), which is not on this map. Cited by 1 paper.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Heat Therapy Compared With Strength Training on Metabolic Profile, Heat Shock Response, Inflammation, Cardiovascular Responses and Microbiota in Individuals With Type 2 Diabetes
Who cites it
1 citing paper in PubMed.
- Thermal stress: an untapped potential in rehabilitation? An opinion paper on Finnish sauna and whole-body cryostimulation.Frontiers in rehabilitation sciences · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInterventions capable of modulating the heat shock response (HSR), such as physical exercise and heat therapy (HT), are potential therapeutic strategies for the prevention and treatment of diabetes.
objectiveThis study aims to evaluate the effects of resistance training (RT) and HT on HbA1c levels, metabolic and inflammatory profiles, gut microbiota, and HSR in patients with type 2 diabetes mellitus (T2DM). DESIGN AND
settingA randomized, double-blind, parallel clinical trial will be conducted for 12 weeks in southern Brazil.
methodsParticipants with T2DM will be randomized into control (any intervention), RT, or HT groups. In the RT group, participants will perform supervised exercise, and the HT group will undergo whole-body heat treatment in an environmental chamber initially set at 55.0°C, both on three non-consecutive days of the week (60 min). Blood samples will be collected before and after 12 weeks of treatment. Heat shock response, body composition and physical fitness, glycemic control, lipid profile, gut microbiota composition and diversity, inflammatory markers, and flow-mediated dilation will be evaluated.
conclusionSince the HSR response is decreased in individuals with diabetes, we believe that improving the HSR may be important in preventing chronic complications associated with T2DM. This randomized clinical trial will determine the efficacy of HT compared to RT in improving HSR when combined with conventional therapy in individuals with T2DM. Multiple HT and RT effects may contribute to a lower mortality risk in these individuals. CLINICAL
trial registrationUnique Identifier NCT05847075. https://clinicaltrials.gov/study/NCT05847075.
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