Evidence map›Paper›PMID 40465890›Full record

ReviewRevista da Sociedade Brasileira de Medicina Tropical2025

Cytogenetic Alterations Observed in Exfoliative Cells of the Tongue and Oral Mucosa of SARS-CoV-2-Vaccinated Patients: Report of Two Cases and a Brief Literature Review.

Lucas Alves da Mota Santana, Michelly Kierkegaard Campos de Oliveira, Maria Vitória Conceição Carvalho, Pedro Henrique Macedo Moura, Marina Dos Santos Barreto, Marcos Antônio Lima Dos Santos, Pedro Lima Dos Santos, Dalmo Correia, Virgínia Kelma Dos Santos Silva, Rajiv Gandhi Gopalsamy and 3 more

Abstract readReviewCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Review in Revista da Sociedade Brasileira de Medicina Tropical, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lucas Alves da Mota SantanaUniversidade Federal de Sergipe, Departmento de Odontologia, Aracaju, SE, Brasil.ORCID http://orcid.org/0000-0002-8261-1504
Michelly Kierkegaard Campos de OliveiraUniversidade Tiradentes, Departamento de Odontologia, Aracaju, SE, Brasil.ORCID http://orcid.org/0009-0003-6799-8151
Maria Vitória Conceição CarvalhoUniversidade Tiradentes, Departamento de Odontologia, Aracaju, SE, Brasil.ORCID http://orcid.org/0009-0003-7853-8759
Pedro Henrique Macedo MouraUniversidade Federal de Sergipe, Departmento de Farmácia, São Cristóvão, SE, Brasil.ORCID http://orcid.org/0000-0002-5689-2090
Marina Dos Santos BarretoUniversidade Federal de Sergipe, Departmento de Farmácia, São Cristóvão, SE, Brasil.ORCID http://orcid.org/0000-0003-4724-0688
Marcos Antônio Lima Dos SantosUniversidade de São Paulo, Faculdade de Odontologia, Departamento de Estomatologia, São Paulo, SP, Brasil.ORCID http://orcid.org/0000-0002-7589-4809
Pedro Lima Dos SantosUniversidade Federal de Sergipe, Departamento de Medicina, Laboratório de Patologia, Aracaju, SE, Brasil.ORCID http://orcid.org/0009-0005-9057-8168
Dalmo CorreiaUniversidade Federal de Sergipe, Departmento de Medicina, Aracaju, SE, Brasil.ORCID http://orcid.org/0000-0002-2174-5058
Virgínia Kelma Dos Santos SilvaUniversidade Federal de Sergipe, Departmento de Odontologia, Aracaju, SE, Brasil.ORCID http://orcid.org/0000-0002-2777-8811
Rajiv Gandhi GopalsamyRajagiri College of Social Sciences, Division of Phytochemistry and Drug Design, Department of Biosciences, Kochi, Kerala, India.ORCID http://orcid.org/0000-0003-4030-0879
Cleverson Luciano TrentoUniversidade Federal de Sergipe, Departmento de Odontologia, Aracaju, SE, Brasil.ORCID http://orcid.org/0000-0002-1079-4217
Lysandro Pinto BorgesUniversidade Federal de Sergipe, Departmento de Farmácia, São Cristóvão, SE, Brasil.ORCID http://orcid.org/0000-0002-1721-1547
Wilton Mitsunari TakeshitaUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Odontologia, Departamento de Diagnóstico e Cirurgia, Araçatuba, SP, Brasil.ORCID http://orcid.org/0000-0001-5682-1498

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The wide distribution of angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) in oral tissues, especially in the salivary glands, which are natural reservoirs of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), contributes to the classification of the oral cavity as a potential target for the development of lesions. Despite the effective response produced by next-generation immunizers, the possibility of immune escape by new lineages of SARS-CoV-2 cannot be refuted. Therefore, we describe here the occurrence of cytogenetic alterations in orally exfoliated cells of immunized individuals and, based on the literature review, call attention to the need to monitor these cases in the post-pandemic period.

Indexed as

Chromosome AberrationsCOVID-19COVID-19 VaccinesMouth MucosaTongueAdultFemaleHumansMaleMiddle AgedSARS-CoV-2COVID-19 Vaccines

Identifiers

PMID40465890
PMCPMC12129134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.