Evidence map›Paper›PMID 40465888›Full record

ArticleRevista da Sociedade Brasileira de Medicina Tropical2025

Quantitative PCR for parasitemia monitoring and preemptive therapy in patients with Chagas disease and autoimmune rheumatic disorders undergoing biologic treatment: a case series.

Noemia Barbosa Carvalho, Vera Lucia Teixeira de Freitas, Nadia Emi Aikawa, Lucas Teixeira Vieira, Rita Cristina Bezerra, Adriana Coraccini Tonácio de Proença, Karina Bonfiglioli, Érika Yoshie Shimoda Nakanishi, Hermes Ryoiti Higashino, Maria Aparecida Shikanai-Yasuda

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In one paragraph

Article in Revista da Sociedade Brasileira de Medicina Tropical, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Noemia Barbosa CarvalhoUniversidade de São Paulo, Divisão de Moléstias Infecciosas do Hospital das Clinicas da Faculdade de Medicina, São Paulo, SP, Brasil.ORCID http://orcid.org/0000-0002-1884-9526
Vera Lucia Teixeira de FreitasUniversidade de São Paulo, Departamento de Infectologia e Medicina Tropical da Faculdade de Medicina, São Paulo, SP, Brasil.ORCID http://orcid.org/0000-0003-1112-081X
Nadia Emi AikawaUniversidade de São Paulo, Divisão de Reumatologia, Hospital das Clinicas da Faculdade de Medicina, São Paulo, SP, Brasil.ORCID http://orcid.org/0000-0002-7585-4348
Lucas Teixeira VieiraUniversidade de São Paulo, Departamento de Infectologia e Medicina Tropical da Faculdade de Medicina, São Paulo, SP, Brasil.ORCID http://orcid.org/0000-0002-3073-9477
Rita Cristina BezerraUniversidade de São Paulo, Laboratório de Investigação Medica em Parasitologia (LIM 46), Hospital das Clinicas da Faculdade de Medicina, São Paulo, SP, Brasil. .ORCID http://orcid.org/0009-0001-6162-9852
Adriana Coraccini Tonácio de ProençaUniversidade de São Paulo, Divisão de Moléstias Infecciosas do Hospital das Clinicas da Faculdade de Medicina, São Paulo, SP, Brasil.ORCID http://orcid.org/0000-0002-1038-8796
Karina BonfiglioliUniversidade de São Paulo, Divisão de Reumatologia, Hospital das Clinicas da Faculdade de Medicina, São Paulo, SP, Brasil.ORCID http://orcid.org/0000-0003-3547-5674
Érika Yoshie Shimoda NakanishiUniversidade de São Paulo, Laboratório de Investigação Medica em Imunologia (LIM 48) do Hospital das Clinicas da Faculdade de Medicina, São Paulo, SP, BR.ORCID http://orcid.org/0000-0002-6928-385X
Hermes Ryoiti HigashinoUniversidade de São Paulo, Divisão de Moléstias Infecciosas do Hospital das Clinicas da Faculdade de Medicina, São Paulo, SP, Brasil.ORCID http://orcid.org/0000-0002-2038-1539
Maria Aparecida Shikanai-YasudaUniversidade de São Paulo, Departamento de Infectologia e Medicina Tropical da Faculdade de Medicina, São Paulo, SP, Brasil.ORCID http://orcid.org/0000-0003-3864-041X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with chronic Chagas disease (CD) and autoimmune rheumatic disorders (ARD) receiving immunosuppressive therapy are at risk for CD reactivation (CDR). This study monitored parasitemia over 9-121 months in six patients with CD and ARD using conventional and quantitative PCR and parasitology. Five patients showed parasitemia; two had elevated levels of parEq/mL (49-458.7). One patient received benznidazole with a marked decrease in parasitemia; in the other, treatment was discontinued after 12 days due to toxicity. No CDR occurred. These findings support the need for qPCR standardization for preemptive therapy and suggest that benznidazole may prevent CDR in patients with high parasitemia.

Indexed as

Autoimmune DiseasesChagas DiseaseNitroimidazolesParasitemiaRheumatic DiseasesTrypanocidal AgentsAdultAgedChronic DiseaseFemaleHumansImmunosuppressive AgentsMaleMiddle AgedPolymerase Chain ReactionReal-Time Polymerase Chain ReactionbenzonidazoleImmunosuppressive AgentsNitroimidazolesTrypanocidal Agents

Identifiers

PMID40465888
PMCPMC12129137

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.