Evidence map›Paper›PMID 40465887›Full record

ArticleRevista da Sociedade Brasileira de Medicina Tropical2025

Investigating the association between yellow fever vaccination and symptomatic acute Zika virus infection: a case-control study.

Lisany Krug Mareto, Sahra de Almdeira Metzker, Camila Guadeluppe Maciel, Bruna Luiza de Amorin Vilharba, Fabio Antonio Venancio, Wagner de Souza Fernandes, Cláudia Du Bocage Santos-Pinto, Everton Falcão de Oliveira

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In one paragraph

Article in Revista da Sociedade Brasileira de Medicina Tropical, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lisany Krug MaretoPrograma de Pós-Graduação em Doenças Infecciosas e Parasitárias, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.ORCID http://orcid.org/0009-0006-9975-5359
Sahra de Almdeira MetzkerFaculdade de Medicina, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.ORCID http://orcid.org/0009-0001-3269-1825
Camila Guadeluppe MacielResidência Multiprofissional em Saúde da Família SESAU/FIOCRUZ, Secretaria Municipal de Saúde de Campo Grande, Campo Grande, MS, Brazil.ORCID http://orcid.org/0000-0003-4317-8506
Bruna Luiza de Amorin VilharbaPrograma de Pós-Graduação em Doenças Infecciosas e Parasitárias, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.ORCID http://orcid.org/0000-0001-7326-2384
Fabio Antonio VenancioPrograma de Pós-Graduação em Doenças Infecciosas e Parasitárias, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.ORCID http://orcid.org/0000-0002-7458-7057
Wagner de Souza FernandesInstituto de Biociências, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.ORCID http://orcid.org/0000-0002-3500-9721
Cláudia Du Bocage Santos-PintoFaculdade de Medicina, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.ORCID http://orcid.org/0000-0002-5478-4977
Everton Falcão de OliveiraPrograma de Pós-Graduação em Doenças Infecciosas e Parasitárias, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.ORCID http://orcid.org/0000-0002-0074-5278

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDuring the Zika virus (ZIKV) epidemic in Latin America (2015-2016), a high incidence of microcephaly was observed in places with low yellow fever (YF) vaccination coverage. Cross-reactivity between ZIKV and YF virus was hypothesized as a possible explanation.

methodsWe performed a case-control study to estimate the odds of ZIKV infection according to patients' YF vaccination status. The study considered ZIKV fever as the outcome, and previous vaccination against YF as exposure. We included all confirmed cases of acute ZIKV fever in Campo Grande, Mato Grosso do Sul, from January 2015 to December 2018. The control group comprised age- and sex-matched residents of Campo Grande who had no history of acute febrile arboviruses during the study period.

resultsThe cumulative incidence of acute ZIKV fever was 1.87 cases per 1000 population. The case group had a predominance of women aged 20-39 years and white and mixed races. Vaccination coverage for YF was 65.5% in the case group and 60.9% in the control group. The odds ratio (OR) suggested a weak association between outcomes and exposure (OR = 1.23; 95% confidence interval [CI]: 1.05-1.44).

conclusionsOur findings provide no evidence that prior YF vaccination protects against acute ZIKV infection. Further studies are needed to analyze the development of anti-ZIKV and anti-YF neutralizing antibodies in affected individuals because new ZIKV epidemics are predicted.

Indexed as

Yellow FeverYellow Fever VaccineZika Virus InfectionAcute DiseaseAdolescentAdultBrazilCase-Control StudiesChildFemaleHumansIncidenceMaleMiddle AgedYoung AdultYellow Fever Vaccine

Identifiers

PMID40465887
PMCPMC12129138

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.