SynthesisBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2025
Changes in microRNA expression associated with preeclampsia: a systematic review.
Synthesis in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epigenetic alterations in preeclampsia: a systematic review of current mechanisms and biomarker potential.Journal of medicine and life · 2026Pooled it
- The Immunopathology of Preeclampsia.Biomedicines · 2026Review
- Endothelial Dysfunction in Preeclampsia: Focus on the Uteroplacental Circulation.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Disrupting the circTNC/miR-582-5p/MAPK8 axis alleviates oxidative stress-induced trophoblast dysfunction in preeclampsia.Journal of molecular histology · 2026Article
- Preeclampsia as an early manifestation of cardiovascular-kidney-metabolic syndrome.Frontiers in physiology · 2026Article
- Sex Differences in Hypertension Risk: Insights from Placental Genomics and Pregnancy-Driven Vascular Programming.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preeclampsia (PE) is a disease of pregnancy characterized by the new onset of hypertension accompanied by proteinuria and/or other signs of maternal organ dysfunction that manifests after 20 weeks of gestation. MicroRNAs (miRNAs) are small non-coding RNAs (19-25 nucleotides) that function in the post-transcriptional regulation of gene expression. Many studies have suggested that different microRNA expression profiles may be associated with the development of PE. Hence, this study aims to report differentially expressed microRNAs that may be associated with the pathogenesis of PE and investigate whether different miRNA expression profiles are associated with different PE classifications and different phases of pregnancy. The bibliographic search was conducted from September 2021 to August 2024 and was performed on MEDLINE/PubMed, EMBASE, and Web of Science. This systematic review followed the methodological guidelines of the Cochrane Collaboration Manual for Systematic Intervention Reviews and was written according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Of the 1362 studies identified, 263 articles were selected as the sample of this study. The most frequently cited upregulated microRNAs were: miR-210, miR-155, miR-518b, miR-181a, miR-125b, miR-183, and miR-16. The most frequently cited downregulated microRNAs were: miR-363, miR-18a, miR-144, miR-149, miR-16, miR-18b, and miR-195. This study will serve as a reference to guide future experimental research. In addition, knowledge of the expression profiles of microRNAs associated with PE can help in the development of new protocols for early prediction of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.