ArticlePloS one2025
Comparative analysis of extracellular vesicles from induced and adipose-derived Mesenchymal Stem Cells: Implications for regenerative medicine.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- The Promise and Challenges of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Periodontal Disease.Pathogens (Basel, Switzerland) · 2026Review
- Stem cell extracellular vesicles for neuropsychiatric disorders and translation.Extracellular vesicles and circulating nucleic acids · 2026Review
- Cancer cell-dependent increase in senescence-like populations following exosome treatment from bone marrow and induced pluripotent stem cell-derived mesenchymal stem cells.World journal of stem cells · 2025Article
- Exosomes Derived from Induced and Wharton's Jelly-Derived Mesenchymal Stem Cells Promote Senescence-like Features and Migration in Cancer Cells.International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular vesicles (EVs), which include exosomes (Exos) and microvesicles (MVs), play a crucial role in intercellular communication and exert various biological activities by delivering specific cargoes of functional molecules, such as RNAs and proteins, to target cells. EVs secreted by human mesenchymal stem cells (hMSCs) have demonstrated their capacity to replace intact MSCs in tissue repair and regeneration. Induced mesenchymal stem cells (iMSCs) derived from induced pluripotent stem cells (iPSCs) present a promising alternative to traditional MSCs for producing EVs. This study aimed to establish an alternative source of EVs from iMSCs and compare them with EVs from adipose-derived MSCs (ADMSCs). Both iMSCs and ADMSCs were expanded under xeno-free culture conditions, and conditioned media were collected for EV isolation and characterization. The effects of the isolated EVs on cellular viability, apoptosis, senescence, and cell migration were evaluated. Results indicated that iMSC-EVs had a larger particle size (~1.5-fold) with no significant differences in morphology or surface markers compared to ADMSC-EVs. Furthermore, both iMSC- and ADMSC-derived EVs significantly increased HDF viability at 48 and 72 hours (p ≤ 0.01, p ≤ 0.05). Both types of EVs significantly reduced apoptosis levels (p ≤ 0.01) in both HDFs and ADMSCs, while having no effect on senescence induction (p > 0.9999). Additionally, iMSC-EVs significantly enhanced ADMSC migration (p < 0.0001), whereas the effect was less pronounced with ADMSC-EVs. iMSC-EVs present a promising and a scalable option for regenerative applications, offering advantages over ADMSC-EVs. However, further investigation is needed to fully understand their effects and underlying mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.