Evidence map›Paper›PMID 40465726›Full record

ArticleScience advances2025

A cell-type-specific epigenetic mechanism encodes social investigatory behavior via Lrhcn1 and Hcn1.

Pengwei Qin, Wanting Zhao, Xiaoting Zhou, Yiqing Guo, Lanfang Li, Zhiqiang Liu, Xiya Shen, Chunqing Yang, Xiaomei Tang, Dian Yu and 11 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Pengwei QinInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0009-0009-8999-485X
Wanting ZhaoInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0009-0009-1801-0972
Xiaoting ZhouDepartment of Pathophysiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0009-0006-7677-8240
Yiqing GuoInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0009-0000-7551-0345
Lanfang LiInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0009-0004-6142-9174
Zhiqiang LiuInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0009-0008-9802-214X
Xiya ShenInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.
Chunqing YangInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0009-0000-8770-7348
Xiaomei TangInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0009-0003-2967-9803
Dian YuInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.
Mengzheng ZhuInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.
Shiping WuInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.
Long ChengInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.
Jiahao YangInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0009-0000-4937-3797
Xinyan LiInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0000-0001-5770-8315
Hao LiInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.
Ling-Qiang ZhuInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.
Wei JingInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0000-0001-8054-0725
Hui-Yun DuInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0009-0006-8641-9997
Dan LiuInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0000-0001-8078-4674
Youming LuInnovation Center for Brain Medical Sciences of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0000-0002-2422-5656

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Social investigation is a complex behavior essential for understanding the surrounding world and is impaired in some major neuropsychiatric disorders. Yet, little is known about whether and, if yes, how social investigation is encoded in a specific type of cortical neurons. Here, we generated a computer vision tool to track social behavior of naïve mice and categorized them as high versus low social states. We integrated a genetically guided TRAP2 strategy with single-cell Ca

Indexed as

Behavior, AnimalEpigenesis, GeneticHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsPotassium ChannelsRNA, Long NoncodingSocial BehaviorAnimalsMaleMiceNeuronsNitric Oxide Synthase Type IReceptor, Serotonin, 5-HT2CHcn1 protein, mouseHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsNitric Oxide Synthase Type IPotassium ChannelsReceptor, Serotonin, 5-HT2CRNA, Long Noncoding

Identifiers

PMID40465726
PMCPMC12136044

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.